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ORIGINAL RESEARCH article
Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1513375
This article is part of the Research Topic Endocrinology, Lipids, and Disease: Unraveling the Links View all 11 articles
The Association between Lipid Accumulation Product and Osteoporosis in American Adults: analysis from NHANES dataset
Provisionally accepted
Ke Wang 1 Xiao Long 1 Ping Wu 1 Yongchun Xiao 1 Huanran Liao 1 Wan Li 1 Jianxian Luo 1,2*
Zhisheng Ji 1*- 1 First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China
- 2 The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China
AbstractBackgroundThe Lipid Accumulation Product (LAP), a novel indicator of fat accumulation, reflects the distribution and metabolic status of body fat. This study aims to evaluate the relationship between adult Americans' prevalence of osteoporosis and LAP.MethodsThis study used data from the NHANES cycles 2007-2010, 2013-2014, and 2017-2018, including 4200 adults aged 50 and above. LAP was calculated using waist circumference and triglyceride levels, whereas osteoporosis was identified using information from dual-energy X-ray absorptiometry (DXA) assessments of bone mineral density (BMD). Restricted cubic spline (RCS) analysis was evaluated the relationship between LAP and osteoporosis. Additionally, subgroup analyses were conducted to assess the impact of demographic characteristics and health status on the relationship between LAP and osteoporosis. ResultsLAP and osteoporosis were shown to be significantly inversely correlated in the study. In the unadjusted model, the prevalence of osteoporosis and Log LAP showed a significant negative connection (OR=0.62, 95% CI=0.52-0.74). Osteoporosis prevalence decreased by 45% in the fully adjusted model for every unit rise in Log LAP (OR=0.54, 95% CI=0.44-0.66). RCS analysis revealed a nonlinear association between LAP and osteoporosis prevalence (P-non-linear=0.0025), showing an L-shaped negative correlation. Subgroup studies showed that, regardless of age, sex, ethnicity, or health condition, there was a constant negative connection between LAP and osteoporosis.ConclusionAccording to this study, there is a substantial negative relationship between adult prevalence of osteoporosis in America and LAP. LAP is an easy-to-use and practical indication that may be very helpful in osteoporosis prevention and early detection.
Keywords: Osteoporosis, Lipid accumulation product, triglyceride, Cross-sectional study, NHANES
Received: 18 Oct 2024; Accepted: 25 Feb 2025.
Copyright: © 2025 Wang, Long, Wu, Xiao, Liao, Li, Luo and Ji. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jianxian Luo, First Affiliated Hospital of Jinan University, Guangzhou, 510630, Guangdong Province, China
Zhisheng Ji, First Affiliated Hospital of Jinan University, Guangzhou, 510630, Guangdong Province, China
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