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ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1510756
Red blood cell distribution width to albumin ratio is associated with age-related macular degeneration: A population-based cross-sectional study
Provisionally accepted- Shenzhen Aier Hosipital, Shenzhen, China
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Background: Age-related macular degeneration (AMD) is a prevalent cause of central vision impairment in middle-aged and the old people. There is substantial evidence that AMD is associated with inflammation. The aim of the study was to investigate the association between the inflammatory marker, red blood cell distribution width/albumin ratio (RAR), and AMD.Methods: Our study included 5,370 participants aged over 40 years base on NHANES data from 2005 to 2008. Multivariable logistic regression analysis was used to examine the relationship between RAR and AMD in the study. Smooth curves and the piecewise linear regression model confirmed whether the correlation was linear or nonlinear. Additionally, subgroup analysis and interaction testing were performed.We found a positive linear correlation between RAR and AMD, even after adjusting for covariates. Each unit rise in RAR corresponded to a 30% increase in the odds of AMD prevalence (OR = 1.3; 95% CI, 1.0-1.6). The odds of AMD prevalence was 1.7 times greater in the highest quintile (Q5) group compared to the lowest quintile (Q1) group (OR = 1.7; 95% CI, 1.2-2.5). Higher RAR values, in comparison to lower values, were significantly associated with increased odds of AMD prevalence (P trend < 0.05). Subgroup analyses and interaction tests clarified the stability of the findings.According to this study, there is a positive linear correlation between RAR and the odds of AMD prevalence in American adults. Further research is necessary to clarify the specific physiological mechanisms that underlie the relationship between RAR and AMD.
Keywords: age-related macular degeneration, NHANES, Red blood cell distribution width, albumin, ratio
Received: 13 Oct 2024; Accepted: 25 Mar 2025.
Copyright: © 2025 An, Zeng, Liu, Zhang, Liao, Liu and Qin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bo Qin, Shenzhen Aier Hosipital, Shenzhen, China
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