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ORIGINAL RESEARCH article

Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1509269
This article is part of the Research Topic Cholesterol, inflammation and immunity View all articles

Submission to Frontiers in Medicine

Provisionally accepted
zihan Qin zihan Qin 1yifei Liu yifei Liu 2*yinuo Fang yinuo Fang 2*lingye Zhang lingye Zhang 1*shutain Zhang shutain Zhang 1*
  • 1 Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
  • 2 Hebei Medical University, Shijiazhuang, Hebei Province, China

The final, formatted version of the article will be published soon.

    Background: Helicobacter pylori (Hp) infection is one of the major global health problems resulting in multiple system disorders. The serum uric acid to high density lipoprotein cholesterol ratio (UHR) is a novel index of inflammation and metabolism, but its association with the development of Hp infection is still unclear.Methods: This is a cross-sectional study involving 2,666 participants, using data from the National Health and Nutrition Examination Survey (NHANES) conducted in the United States. The relationship between UHR and Hp infection was evaluated by multivariate logistic regression and sensitivity analysis to enhance the stability of the results.Results: Among all individuals, 1,165 were Hp positive (43.7%) and 1,501 were Hp negative (56.3%).After adjustment, there was a positive correlation between UHR and Hp infection (OR=1.15; 95%CI:1.02-1.30; P=0.020). This association is relatively stable in the subgroup analysis (P>0.05).There is a positive correlation between the UHR and the development of Hp infection in our study. This non-invasive indicator can improve the ability to monitor Hp infection and may find alternative therapeutic intervention targets.

    Keywords: HP, Hp infection, Serum uric acid to high-density lipoprotein cholesterol ratio, Serum uric acid, High-density lipoprotein cholesterol, adults

    Received: 10 Oct 2024; Accepted: 06 Jan 2025.

    Copyright: © 2025 Qin, Liu, Fang, Zhang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    yifei Liu, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China
    yinuo Fang, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China
    lingye Zhang, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
    shutain Zhang, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.