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CLINICAL TRIAL article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 |
doi: 10.3389/fmed.2025.1507352
This article is part of the Research Topic Hospital Acquired Infection in Patients with Cardiovascular Diseases View all 3 articles
Effect of Polyhexamethylene Biguanide (PHMB) Coated Central Venous Catheters on Bacterial Colonization in Cancer Patients Undergoing Abdominal Surgery: A Randomized Controlled Trial
Provisionally accepted- Beijing Cancer Hospital, Peking University, Beijing, Beijing Municipality, China
Background: Central venous catheters (CVCs) are widely used in critically ill patients, including cancer patients, but are associated with complications such as catheter-related bloodstream infections (CRBSI). This study evaluates the effectiveness of polyhexamethylene biguanide (PHMB) coated CVCs in reducing catheter-tip bacterial colonization in cancer patients undergoing abdominal surgery Methods: A prospective, randomized, monocentric clinical trial was conducted at Peking University Cancer Hospital from March 2017 to April 2019. Surgical cancer patients requiring CVCs were randomized into two groups: a PHMB-coated CVC group (Certofix® protect) and a standard CVC group (Certofix®). The primary outcome was catheter-tip bacterial colonization, and secondary outcomes included catheter retention time and hospital length of stay.Results: A total of 1,185 patients were included in the analysis. The incidence of catheter-tip bacterial colonization was 2.5% in the PHMB-coated group and 4.2% in the standard CVC group (P = 0.10). Hospital length of stay was significantly shorter in the PHMB-coated group (P <.001). Subgroup analysis showed reduced bacterial colonization in male patients in the PHMB-coated group (P = 0.04).PHMB-coated CVCs did not significantly reduce catheter-tip bacterial colonization in the overall population, but showed a beneficial effect in male cancer patients undergoing abdominal surgery. When applying catheters in clinical practice, it is necessary to combine various factors to choose the type of catheter.
Keywords: Central venous catheter (CVC), catheter-related bloodstream infection (CRBSI), Bacterial colonization, PHMB, p-hydroxymercuribenzoate, cancer patients
Received: 07 Oct 2024; Accepted: 05 Feb 2025.
Copyright: © 2025 Dong, Yang, Li, Xu, Shen and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jun Dong, Beijing Cancer Hospital, Peking University, Beijing, 100142, Beijing Municipality, China
Qi Li, Beijing Cancer Hospital, Peking University, Beijing, 100142, Beijing Municipality, China
Jia-Xuan Xu, Beijing Cancer Hospital, Peking University, Beijing, 100142, Beijing Municipality, China
Yan-Fen Shen, Beijing Cancer Hospital, Peking University, Beijing, 100142, Beijing Municipality, China
Hong-Zhi Wang, Beijing Cancer Hospital, Peking University, Beijing, 100142, Beijing Municipality, China
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