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ORIGINAL RESEARCH article

Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1504892

Association of dietary niacin intake with osteoporosis in the postmenopausal women in the US: NHANES 2007-2018

Provisionally accepted
Li Li Li Li 1Wankun Liang Wankun Liang 1Bing Deng Bing Deng 2Yue Jiang Yue Jiang 2Xiaomin Huang Xiaomin Huang 1Yanlin Zhang Yanlin Zhang 1Tianrui Lu Tianrui Lu 1Lu Wang Lu Wang 1Yunxiang Xu Yunxiang Xu 2*Guizhen Chen Guizhen Chen 1*
  • 1 The seventh clinical medical college of Guangzhou University of Chinese Medicine, Shenzhen, China
  • 2 Clinical Medical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine,, Guangzhou, China

The final, formatted version of the article will be published soon.

    Background: Elderly individuals with inadequate vitamin B level are at increased risk of degenerative conditions, notably cardiovascular disorders, cognitive impairments, and osteoporosis.The relationship between niacin (vitamin B3) consumption and osteoporosis risk remains a subject of debate. This study aimed to clarify the relationship between dietary niacin intake and the incidence of osteoporosis in postmenopausal women aged ≥50 years.In this study, we gathered details on participants' bone mineral density, osteoporosis status, dietary niacin intake, and several other critical variables. Multivariate logistic regression models were constructed to determine the association between dietary niacin intake and the incidence of osteoporosis. Restricted cubic splines were employed to further assess the linearity and explore the shape of the dose-response associations. Additionally, we performed stratified and interaction analyses to illustrate the stability of the observed relationships across different subgroups.After adjusting for all covariates, there was a significant inverse association with osteoporosis (OR = 0.87; 95% CI: 0.77-0.97; p = 0.016). A negative relationship was observed between dietary niacin intake and the risk of osteoporosis (nonlinear: p = 0.672). While stratified analyses revealed some differences in the association between dietary niacin intake and osteoporosis risk, these differences were not statistically significant.Dietary niacin intake exhibited an inverse correlation with the incidence of osteoporosis. The risk of osteoporosis was significantly reduced by 13% with every 10 mg/day increase in daily dietary niacin consumption among postmenopausal women.

    Keywords: niacin intake, Osteoporosis, Bone health, postmenopausal women, National health and nutrition survey

    Received: 01 Oct 2024; Accepted: 23 Jan 2025.

    Copyright: © 2025 Li, Liang, Deng, Jiang, Huang, Zhang, Lu, Wang, Xu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yunxiang Xu, Clinical Medical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine,, Guangzhou, China
    Guizhen Chen, The seventh clinical medical college of Guangzhou University of Chinese Medicine, Shenzhen, China

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