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REVIEW article

Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1504749
This article is part of the Research Topic Chronic Atrophic Gastritis: Pathogenesis, Diagnostic Challenges, and Gastric Cancer Risk View all articles

Association of Helicobacter pylori related Chronic Atrophic Gastritis and Gastric Cancer Risk: A Literature Review

Provisionally accepted
ZEFENG ZHANG ZEFENG ZHANG 1*Sitong Chen Sitong Chen 2Shudan Li Shudan Li 2Yadan Zheng Yadan Zheng 2Lifei Mai Lifei Mai 2Xiaoguang Zhang Xiaoguang Zhang 1
  • 1 Department of Digestive Endoscopy Center, Guangdong Provincial People's Hospital, Guangzhou, China
  • 2 Department of Internal Medicine, Guangdong Provincial People's Hospital, Guangzhou, China

The final, formatted version of the article will be published soon.

    Chronic atrophic gastritis (CAG) is considered to be closely related to Helicobacter pylori (H. pylori) infection and characterized by the atrophy and/or intestinal metaplasia (IM) of the gastric mucosa in pathology. CAG is often regarded as the precancerous lesion of gastric cancer and H. pylori infection stimulates the development of atrophy and IM and the progression of gastric cancer through the persistent effect acting on the gastric mucosa, including releasing inflammatory factors such as Interleukin-8(IL-8). From the molecular biology perspective, growing evidence shows that H. pylori probably induce the expression of NF-κB, miR-204, miR-27a, hnRNPA2B1 and JARID1B, which play crucial roles in the progression of CAG into gastric cancer. In addition, H. pylori can increase Epstein-Barr virus (EBV) infection, and the co-infection will jointly increase gastric cancer risk. Furthermore, H. pylori induces cellular senescence and promotes atrophy progression and finally increases the gastric cancer risk. This review aims to explore the carcinogenic mechanisms of H. pylori related CAG in order to provide theoretical foundations for the pathogenesis mechanism and early detection and prevention of gastric cancer.

    Keywords: ：chronic atrophic gastritis, Gastric cancer risk, Precancerous lesion, Helicobacter pylori, intestinal metaplasia

    Received: 01 Oct 2024; Accepted: 06 Jan 2025.

    Copyright: © 2025 ZHANG, Chen, Li, Zheng, Mai and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: ZEFENG ZHANG, Department of Digestive Endoscopy Center, Guangdong Provincial People's Hospital, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.