Vitiligo: a Call for Paradigm Shift Towards Comprehensive Patient Care

Julia Sigova ^1* Maria Borodina ² Konstantin Lomonosov ³ Nigora Murotova ⁴ Aliya Kassymkhanova ⁵ Torello Lotti ⁶

• ¹ Pirogov Russian National Research Medical University, Moscow, Russia
• ² Russian Children's Clinical Hospital, Moscow, Moscow Oblast, Russia
• ³ I.M. Sechenov First Moscow State Medical University, Moscow, Moscow Oblast, Russia
• ⁴ Ministry of Innovative Development of Uzbekistan, Tashkent, Uzbekistan
• ⁵ Vitiligo Clinic, Almaty, Kazakhstan
• ⁶ Department of Dermatology, University of Guglielmo Marconi, Rome, Lazio, Italy

Vitiligo: a Call for Paradigm Shift Towards Comprehensive Patient CareSigova J1,2*, Borodina M3, Kasymkhanova A4, Murotova N5, Lomonosov KM6, Lotti T2(1) Department of Neonatology, Faculty of Continued Medical Education of Pirogov Russian National Research Medical University, Moscow, Russia(2) Department of Dermatology, University of Studies Guglielmo Marconi, Rome, Italy(3) Russian Children's Clinical Hospital of Pirogov Russian National Research Medical University, Moscow, Russia(4) Vitiligo Center, Almaty, Kazakhstan(5) Center for the Development of professional qualifications of medical workers, Department of Medical Engineers and Technicians in Medical and Innovative Technologies, Uzbekistan(6) Department of Dermatology and Communicable Diseases, First Medical State University of Moscow I. M. Sechenev Ministry of Health, Moscow, Russia*Correspondence: Julia Sigova sigovay@gmail.com Keywords: vitiligo, quality of life, artificial intelligence, psychosocial, psychiatric comorbidities1. IntroductionVitiligo affects millions globally, yet care remains fragmented and insufficiently holistic. This work builds on the EADV Task Force's position on quality of life (QoL), proposing a paradigm shift that redefines vitiligo as a complex condition with physical, psychological, and social dimensions. 1 Beyond dermatologic concerns, this approach integrates emerging tools like artificial intelligence (AI) and emphasizes comprehensive care to improve patient outcomes.2. Real-World Considerations in VitiligoPrevalence and ImpactVitiligo affects 0.5–1.5% of the global population, disproportionately impacting youth and working-age adults. 2 Societal biases against skin variations exacerbate the psychological and social challenges faced by individuals, particularly in regions where skin color holds significant cultural importance.Triggers and Aggravation FactorsVitiligo is complex, with multiple potential triggers and aggravating factors that may persist even after successful treatment. These include physical trauma (Koebner phenomenon), emotional stress, hormonal changes, and exposure to certain chemicals or medications. Recent metagenomic sequencing study demonstrates a credible basis for exploring altered gut microbiota in patients with non-segmental vitiligo. 3, 4 In some Central Asian countries, like Kazakhstan and Uzbekistan, hospital intake screening often reveals gut dysbiosis and parasitic infestations in vitiligo patients, emphasizing the need for local research and tailored interventions.Psychiatric ComorbiditiesThe prevalence of psychiatric comorbidities among vitiligo patients is alarmingly high. Studies report a wide range of prevalence for depression (0.1-62.3%) and anxiety (1.9-67.9%).5 Vitiligo patients also have a significantly higher risk of obsessive-compulsive disorder, adjustment disorders, social phobia, and sleep disturbances. 6 Suicidal ideation is a significant concern, particularly in children and adolescents with vitiligo.In line with these observations, we propose a detailed psychological screening protocol. This includes administering validated tools such as the Patient Health Questionnaire-9 (PHQ-9) for depression and the Generalized Anxiety Disorder-7 (GAD-7) for anxiety. Additionally, referrals to mental health professionals should be routine for patients exhibiting signs of psychiatric distress.Physiological Impact Beyond the SkinVitiligo's physiological impact extends beyond the skin, with links to visual and auditory abnormalities, and heart conditions. 7 The role of resident memory T cells (TRM) emphasizes the connection between vitiligo and the nervous system. 8 This interaction may contribute to the pathogenesis of organ-specific autoimmune disorders often associated with vitiligo, such as inflammatory bowel disease, multiple sclerosis, and type 1 diabetes mellitus.Psychosocial ImplicationsVitiligo significantly impacts patients' emotional well-being and social interactions. 9 Many individuals experience stress, anxiety, depression, and low self-esteem, often feeling self-conscious about their appearance. Social stigma further exacerbates these challenges, as patients may face ostracism, teasing, and misconceptions about the disease being contagious. This stigma can affect personal relationships, career opportunities, and marriage prospects, particularly in communities where skin conditions carry strong social stigma.Economic and Familial ConsiderationsAssessing both healthcare and non-healthcare costs associated with vitiligo is crucial, particularly in countries lacking government or commercial insurance support. 10 The impact on parents' mental health, quality of life, and socioeconomic status must also be considered, especially in developing countries where cultural and social pressures exacerbate these challenges.3. Artificial Intelligence in Vitiligo ManagementAI holds significant promise for managing vitiligo, especially in developing countries with limited access to advanced treatments and basic phototherapy tools. 11 However, current AI diagnostic systems struggle due to a lack of diverse image datasets, particularly for populations with skin of color (SOC). 12A major limitation is regional bias in training datasets. The commonly used Fitzpatrick Skin Phototype scale fails to fully capture the range of SOC tones, especially in regions like Central Asia. Addressing this requires collaboration with local healthcare providers and the integration of more inclusive classifications, such as the Monk Skin Tone Scale, to improve diagnostic accuracy.Other challenges include the high cost of AI integration and technological gaps in underserved areas. Partnerships with nonprofits and government programs can help overcome these barriers by subsidizing deployment and training healthcare workers in AI-assisted care.A notable example of an AI application in resource-limited settings is the AI-Guide on Vitiligo, developed by the non-profit Vitiligo Research Foundation (VRF). 13 Acting as a prototype for future teledermatology and patient support services, this human-like AI avatar now provides real time responses via text, voice, or video. It expertly covers topics from triggers to mental health, explores a full range of treatment options, and connects patients with nearby specialists.4. Proposed Comprehensive Care ApproachWe propose reframing vitiligo as a condition requiring comprehensive care, aligning with the World Health Organization's definition of health as encompassing physical, mental, and social well-being. This holistic approach involves the following five key components:Routine Psychological Screening: Conducting regular assessments for psychological distress and psychiatric comorbidities in vitiligo patients using tools like PHQ-9 and GAD-7.Multidisciplinary Care Teams: Establishing integrated teams of dermatologists, mental health professionals, and social workers to address comprehensive patient needs.Expanded Research Focus: Prioritizing research into treatments that address both skin repigmentation and psychosocial well-being.Enhanced Healthcare Provider Education: Training on the psychological impacts of vitiligo, supported by studies demonstrating the benefits of empathy-driven care.AI-Driven Tools Integration: Leveraging advanced AI tools for precise diagnostics and tailored treatment pathways. Developing AI algorithms based on the Monk rather than Fitzpatrick scale, which better accounts for diverse skin color and ethnic background.This approach would offer more accurate, culturally sensitive diagnostics and treatment pathways, particularly benefiting populations with skin of color.5. DiscussionVitiligo is a multifaceted condition requiring a holistic approach that integrates physical, psychological, and systemic factors. Addressing gut health, psychiatric comorbidities, and societal stigma is vital for improving QoL. AI offers promise in enhancing care but must be implemented equitably, with attention to data inclusivity and regional representation, to avoid gaps in AI training datasets and algorithms.This paradigm shift underscores the importance of patient-centered, multidisciplinary care in transforming vitiligo management and achieving meaningful improvements in QoL for affected individuals.Author ContributionSJ — conceptualization and revisions KA, MN, LKM — drafting and editingBM — literature search and editingLT — expert guidance and critical revision of the manuscript. All authors reviewed and approved the submitted form of the manuscript.Conflict of Interest The authors declare that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.Funding The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.