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ORIGINAL RESEARCH article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 |
doi: 10.3389/fmed.2025.1502804
Nonlinear Associations between CD4+ T-Cell Counts and Mortality Risk in People Living with HIV: Evidence from a 10-year Cohort Study
Provisionally accepted
Ruohan Sun 1
Huangchao Jia 2* Qiujia Kang 1* Yanmin Ma 3* Zichen He 1* Xiuxia Ma 2* Jun Yuan 2* Huijun Guo 2* Qianlei Xu 2* Yantao Jin 2*- 1 Henan University of Chinese Medicine, 请选择, China
- 2 First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
- 3 Henan Provincial Center for Disease Control and Prevention, Zhengzhou, China
Background: To investigate the dose-response associations between CD4+ T-cell counts and mortality risk in people living with HIV (PLHIV).: Data on PLHIV from the routine treatment database in Henan Province of China with a high prevalence of acquired immune deficiency syndrome (AIDS) was retrospectively collected, spanning the period from October 2003 to October 2021. We randomly selected 1000 PLHIV in each of he age groups 30, 40, 50, and 60 years respectively who met the inclusion criteria as study individual. The Kaplan-Meier analysis, the COX proportional hazard regression model and the restricted cubic spline (RCS) model was employed to analyze the associations between CD4+ T-cell counts and mortality risk in PLHIV.Results: A total of 4000 participants were enrolled in the study, with followed for 28,158 person-years. During this period, there were 941 (23.5%) deaths, the mortality rate was 3.34/100 person-years, the mean duration of follow-up of 6.77±3.45 years and the cumulative survival rate was 76.5%. The COX proportional hazard regression model revealed that as CD4+ T-cell count increased, the hazard ratio (HR) value
Keywords: CD4+ T-cell count, mortality risk, Cox proportional hazard regression model, Restricted cubic spline, Nonlinear associations
Received: 13 Oct 2024; Accepted: 29 Jan 2025.
Copyright: © 2025 Sun, Jia, Kang, Ma, He, Ma, Yuan, Guo, Xu and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Huangchao Jia, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
Qiujia Kang, Henan University of Chinese Medicine, 请选择, China
Yanmin Ma, Henan Provincial Center for Disease Control and Prevention, Zhengzhou, China
Zichen He, Henan University of Chinese Medicine, 请选择, China
Xiuxia Ma, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
Jun Yuan, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
Huijun Guo, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
Qianlei Xu, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
Yantao Jin, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
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