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CASE REPORT article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1501242
This article is part of the Research Topic Case Reports in Pulmonary Medicine 2024 View all 27 articles
The activation, clinical course, and clinical outcome using an unconventional electrode configuration in a patient newly implanted with Inspire ® therapy: a case report
Provisionally accepted- 1 Wesper, New York, United States
- 2 The Arizona Insomnia and Sleep Institute, Scottsdale, Arizona, United States
Hypoglossal Nerve Stimulation therapy via the Inspire ® implant is a common alternative to positive airway pressure treatment of obstructive sleep apnea. While HGNS therapy offers a high rate of successful treatment outcomes, the post-activation care pathway involving gradual titration of the amplitude to achieve both subjective and objective improvements can be lengthy, ranging from 3-12 months post-activation. Here, we report a case of a 55-year-old male with severe obstructive sleep apnea and history of hypertension who was successfully activated and titrated to achieve subjective and objective relief within eight weeks post-implantation and five weeks postactivation using an unconventional starting electrode configuration. This case demonstrates the need for further exploration of alternative Inspire® activation and management protocols that may lead to improved patient outcomes and higher success rates.
Keywords: Obstructive Sleep Apnea1, sleep disorders2, Hypoglossal Nerve Stimulation3, Inspire ® 4, Hypoxic Burden5, CPAP Intolerance6, Care Pathways7
Received: 24 Sep 2024; Accepted: 10 Feb 2025.
Copyright: © 2025 Rohrscheib and Patel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ruchir P Patel, The Arizona Insomnia and Sleep Institute, Scottsdale, 85255, Arizona, United States
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