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CASE REPORT article

Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1501192
This article is part of the Research Topic Case Reports in Pulmonary Medicine 2024 View all 24 articles

The value of early application of mNGS technology in the diagnosis and treatment of severe Legionnaires' disease: Reports of two cases with different outcomes

Provisionally accepted
Jianqing Fang Jianqing Fang *Zhe Wang Zhe Wang Yu Shen Yu Shen Xuenong Wu Xuenong Wu Hao Fang Hao Fang Xiaokui Sun Xiaokui Sun Ting Yu Ting Yu Qingqing Zhang Qingqing Zhang
  • Hangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Background: Legionnaires' disease has a high clinical mortality rate, and early diagnosis and treatment are critical. Increasing evidence shows that metagenomic next-generation sequencing (mNGS) has excellent potential for the early identification of pathogens. To help clinicians better recognize Legionnaires' disease in its early stage and to illustrate the diagnostic value of mNGS technology, we reviewed and summarized two cases of severe Legionnaires' disease.Methods and analysis: We selected two patients with severe Legionnaires' disease who were admitted to our department in recent years.We discuss experience with them and the shortcomings in their treatment by summarizing their medical history, disease evolution, tests, and diagnostic and therapeutic processes.Results: In both patients, the diagnosis of Legionnaires' disease was confirmed through analysis of the bronchoalveolar lavage fluid (BALF). The middle-aged male patient was cured and discharged due to early detection and diagnosis. The elderly immunocompromised patient died due to a delay

    Keywords: Legionellosis, Legionnaires' Disease, case report, Severe community-acquired pneumonia, Severe hospital-acquired pneumonia

    Received: 24 Sep 2024; Accepted: 13 Jan 2025.

    Copyright: © 2025 Fang, Wang, Shen, Wu, Fang, Sun, Yu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jianqing Fang, Hangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, Jiangsu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.