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SYSTEMATIC REVIEW article
Front. Med.
Sec. Rheumatology
Volume 12 - 2025 |
doi: 10.3389/fmed.2025.1498503
This article is part of the Research Topic Study on Immune Mechanism and Immune Intervention in Connective Tissue Diseases View all 10 articles
Efferocytosis and Inflammation: A Bibliometric and Systematic Analysis
Provisionally accepted- department of rheumatology & immunology, the second xiangya hospital, Changsha, China
Objective: To visualize and analyze the trends and hotspots of efferocytosis and inflammation via bibliometric methods. Methods: Relevant articles and reviews from 2006-2023 were retrieved from the Web of Science Core Collection. The data were processed with CiteSpace, and some graphs were generated with Microsoft Excel (version 2016), VOSviewer, Scimago Graphica, Bibliometrix and R Studio. Results: A total of 1003 papers were included, revealing a significant upward trend in efferocytosis and inflammation research. The United States (456, 45.46%), China (164, 16.35%) and the United Kingdom (99, 9.87%) were the three countries with the highest numbers of publications. Harvard University (84, 6.74%) contributes the most out of the top 5 institutions. Among the researchers in this field, Serhan CN was the author with the highest number of articles in the field (35, 3.49%), and deCathelineau AM first named “efferocytosis” in 2003. Keyword analysis identified"activation", "tam receptors", "docosahexaenoic acid", "systemic lupus erythematosus", "myocardial infarction" and "alveolar macrophages" as core topics, indicating a concentrated trend in the mechanism of physiological state and inflammatory diseases such as autoimmune, cardiovascularand pulmonary diseases. The latest surge words "inflammation resolution" and "cancer" in the keyword heatmap indicate future research directions. Conclusion: Research on the association between efferocytosis and inflammation has been a promising field. Key areas of focus include the crucial role of efferocytosis on tissue homeostasis and the pathogenesis of nontumorous inflammatory diseases. Future research will likely continue to explore these frontiers, with an emphasis on understanding efferocytosis in the context of chronic diseases and cancer, as well as developing novel therapeutic strategies.
Keywords: Efferocytosis, Inflammation, Bibliometrics, molecular mechanism, Mesenchymal Stem Cells, nontumorous inflammatory diseases, Cancer
Received: 19 Sep 2024; Accepted: 22 Jan 2025.
Copyright: © 2025 Cao, Li, Xie, Ling, Tang, He, Tian and Ge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xi Xie, department of rheumatology & immunology, the second xiangya hospital, Changsha, China
Guanghui Ling, department of rheumatology & immunology, the second xiangya hospital, Changsha, China
Xiaoyu Tang, department of rheumatology & immunology, the second xiangya hospital, Changsha, China
Jing Tian, department of rheumatology & immunology, the second xiangya hospital, Changsha, China
Yan Ge, department of rheumatology & immunology, the second xiangya hospital, Changsha, China
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