Exploring the Prognostic Value of the Novel Nutritional Index for In-Hospital Mortality in Acute Coronary Syndrome: A Sex-Specific Analysis

Guimei Li ShuJuan Li ^*

• Affiliated Hospital, Inner Mongolia Medical University, Hohhot, China

Background: Emerging evidence suggests that nutritional status plays a pivotal role in determining the prognosis of patients with acute coronary syndrome (ACS). This study aimed to investigate the relationship between a novel nutritional index, Triglycerides × Total Cholesterol × Body Weight Index (TCBI), and short-term prognosis in patients with ACS.Methods: A retrospective study was conducted using data from 5,277 ACS patients admitted to intensive care units of 208 U.S. hospitals in the eICU Collaborative Research Database (eICU-CRD) in 2014 and 2015. Patients were divided into three groups based on TCBI tertiles: Group 1 (<1017.97), Group 2 (1017.97-2069.02), and Group 3 (>2069.02).Results: Multivariate logistic regression analysis showed that after adjusting for 17 confounding variables, higher TCBI had significantly lower in-hospital mortality [Tertile3 vs Tertile1: OR (95% CI): 0.67 (0.48, 0.94), p = 0.019]. This relationship was significant in the male subgroup but not in the female subgroup. The association between TCBI and in-hospital mortality was more pronounced in male patients and those with blood pressure >140 mmHg. Subgroup analysis revealed a significant interaction between sex and the predictive value of TCBI (p for interaction < 0.05). Conclusion: Higher TCBI was independently associated with decreased in-hospital mortality in ACS patients, particularly in male patients. TCBI, as a novel nutritional index, may serve as a practical tool for risk stratification and personalized management of ACS patients.