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SYSTEMATIC REVIEW article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1497703
Association between obstructive sleep apnea and multiple adverse clinical outcomes: evidence from an umbrella review
Provisionally accepted- West China Hospital, Sichuan University, Chengdu, China
Background and Objective: In recent years, there has been a notable rise in awareness regarding obstructive sleep apnea (OSA), and a significant number of potential OSA cases have been identified. Numerous studies have established associations between OSA and various adverse clinical outcomes. This umbrella review aims to summarize and evaluate the available evidence on the relationship between OSA and multiple adverse clinical outcomes.Methods: PubMed, Embase, and Web of Science databases were systematically searched from inception to September 2023. The AMSTAR and GRADE were used to evaluate the quality of meta-analysis literature and classify the quality of literature evidence. Furthermore, the size of the effect size of the association between OSA and adverse clinical outcomes were assessed by using either a random or fixed-effect model and 95% confidence interval (CI).Results: A total of 27 meta-analyses were enrolled with 43 adverse clinical outcomes. The umbrella review primarily reported the associations between sleep apnea syndrome and thyroid cancer (HR=2.32,95%CI:1.35-3.98)， kidney
Keywords: obstructive sleep apnea, adverse clinical outcomes, Umbrella review, Meta-analysis, apnea-hypopnea index
Received: 17 Sep 2024; Accepted: 26 Feb 2025.
Copyright: © 2025 Wang, Zeng, Dai, Zhang and SHEN. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
PENGFEI SHEN, West China Hospital, Sichuan University, Chengdu, China
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