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ORIGINAL RESEARCH article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1496834
Expression and Diagnostic Values of Ferroptosis-Related Genes in Coronavirus-Associated Viral Sepsis
Provisionally accepted- 1Shanxi Medical University, Taiyuan, China
- 2Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, Shanghai, China
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The aim of this study is to investigate the differential expression and diagnostic value of ferroptosis-related genes in coronavirus-associated viral sepsis.This study was conducted in two sequential phases: (1) identification of differentially expressed genes through comprehensive analysis of the experimental dataset (GSE164805); and (2) clinical validation of the candidate molecular markers using both test set samples and clinical samples, followed by rigorous evaluation of their diagnostic performance. Firstly, the microchips associated with coronavirus-associated viral sepsis were retrieved from the GEO database, a public data platform of NCBI (National Center for Biotechnology Information), and differentially expressed genes (DEGs) were obtained through differential analysis. The identified DEGs were then intersected with the ferroptosis gene dataset to obtain ferroptosis-related DEGs.Subsequently, molecular signaling pathways of ferroptosis-related genes in coronavirusassociated viral sepsis were analyzed using gene ontology (GO) and Kyoto Encyclopedia 0.107), HMOX1 (0.629 ± 0.117 vs 1.101 ± 0.107), and the differences were statistically significant (all P < 0.05). Further diagnostic performance analysis demonstrated that IL1β and HMOX1 exhibited AUROCs of 0.892 and 0.765, respectively, indicating their robust diagnostic potential for coronavirus-associated viral sepsis. Conclusion The present study has successfully identified two hub genes, IL1-β and HMOX1, associated with ferroptosis in coronavirus-associated viral sepsis, and their expression and diagnostic value for the disease. These findings provide effective diagnostic biomarkers and potential therapeutic targets for coronavirus-associated viral sepsis. Notably, this study specifically focused on coronavirus-induced viral sepsis, distinct from previously characterized bacterial sepsis and other viral etiologies, thus warranting future studies with expanded sample sizes for stratified analyses.
Keywords: ferroptosis, Coronavirus, Viral sepsis, IL1-β, HMOX1
Received: 15 Sep 2024; Accepted: 08 Apr 2025.
Copyright: © 2025 Zhang, Wu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoyan Li, Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, Shanghai, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.