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CASE REPORT article

Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1490820

Pulmonary arteriovenous malformation causing lung sequestration and media infarction: a case report

Provisionally accepted
Raffaella Griffo Raffaella Griffo 1*Laura V. Klotz Laura V. Klotz 1,2Lena Brendel Lena Brendel 1Romina Rösch Romina Rösch 1Benedikt Niedermaier Benedikt Niedermaier 1Kai Schlamp Kai Schlamp 3Mark Kriegsmann Mark Kriegsmann 2,4Martin M. Eichhorn Martin M. Eichhorn 1,2Hauke Winter Hauke Winter 1,2
  • 1 Klinik für Thoraxchirurgie, Thoraxklinik, Universität Heidelberg, Heidelberg, Baden-Württemberg, Germany
  • 2 Translational Lung Research Center, Heidelberg University Hospital, Heidelberg, Baden-Württemberg, Germany
  • 3 Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoracic Clinic, Heidelberg University Hospital, Heidelberg, Baden-Württemberg, Germany
  • 4 Institute of Pathology, Heidelberg University Hospital, Heidelberg, Baden-Württemberg, Germany

The final, formatted version of the article will be published soon.

    Pulmonary arteriovenous malformations (PAVMs) are rare vascular malformations of the lungs. Direct communication of pulmonary arteries to pulmonary veins is the defining characteristic allowing venous blood to bypass the pulmonary capillary system and avoiding an efficient oxygenation process. The complexity of the pathology lies not only in the variety of its manifestations, but also in the choice of the most appropriate and effective treatment. We present a case of a complex PAVM associated with a persistent foramen ovale, with stroke as the onset symptom. Despite timely multidisciplinary treatment of the malformation, a potentially fatal pulmonary complication occurred, highlighting the critical importance of early, interdisciplinary management and ongoing follow-up of PAVMs, particularly in preventing life-threatening outcomes.

    Keywords: Lung malformation, Thoracic Surgery, Pulmonary arteriovenous malformations, Hereditary hemorrhagic telangiectasia, lung disease, case report

    Received: 03 Sep 2024; Accepted: 20 Jan 2025.

    Copyright: © 2025 Griffo, Klotz, Brendel, Rösch, Niedermaier, Schlamp, Kriegsmann, Eichhorn and Winter. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Raffaella Griffo, Klinik für Thoraxchirurgie, Thoraxklinik, Universität Heidelberg, Heidelberg, 69126, Baden-Württemberg, Germany

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