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SYSTEMATIC REVIEW article

Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1489991

Heart disease in pregnancy and adverse outcomes: Umbrella review

Provisionally accepted
Jiani Zhang Jiani Zhang 1Yuxin Ren Yuxin Ren 1*Bingjie Li Bingjie Li 2Qi Cao Qi Cao 1Xiaodong Wang Xiaodong Wang 1*Haiyan Yu Haiyan Yu 1*
  • 1 West China Second University Hospital, Sichuan University, Chengdu, China
  • 2 National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative Drugs, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Background: Heart disease in pregnancy encompasses both congenital heart disease and maternal acquired heart disease, both of which are associated with an increased risk of various adverse outcomes for mothers and their offspring. Objective: To review and summarize the evidence regarding the association between heart disease in pregnancy and adverse outcomes in mothers and their offspring. Data sources: A comprehensive search was conducted in Embase, PubMed, Web of Science and the Cochrane Database of Systematic Reviews from inception to March 2024. Results: A total of twelve meta-analyses and systematic reviews were included, which documented 156 adverse outcomes for mothers and 65 adverse outcomes for offspring were yielded. Evidence was found for both primary and secondary adverse outcomes. Conclusions: Current evidence links heart disease during pregnancy to adverse maternal outcomes, including death and cardiac, pulmonary, and cerebrovascular events, as well as increased mortality risk for offspring. Many meta-analyses in this field have limitations that raise concerns about their validity, highlighting the need for high-quality prospective studies.

    Keywords: Adverse outcomes, Heart disease, Meta-analysis, Pregnancy, umbrella adverse outcomes, Umbrella review

    Received: 02 Sep 2024; Accepted: 20 Jan 2025.

    Copyright: © 2025 Zhang, Ren, Li, Cao, Wang and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuxin Ren, West China Second University Hospital, Sichuan University, Chengdu, China
    Xiaodong Wang, West China Second University Hospital, Sichuan University, Chengdu, China
    Haiyan Yu, West China Second University Hospital, Sichuan University, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.