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SYSTEMATIC REVIEW article

Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1484656
This article is part of the Research Topic Community Series in Gut Microbiota and Immunity in Health and Disease: Dysbiosis and Eubiosis's Effects on the Human Body, Volume II View all articles

The role of Akkermansia muciniphila in maintaining health: a bibliometric study

Provisionally accepted
Fangfang Gao Fangfang Gao 1Canyu Cheng Canyu Cheng 2Zongcun Chen Zongcun Chen 3Ke Tang Ke Tang 2Runwei Li Runwei Li 2Guankui Du Guankui Du 2*
  • 1 First Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China
  • 2 Hainan Medical University, Haikou, China
  • 3 Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China

The final, formatted version of the article will be published soon.

    Background: Akkermansia muciniphila , as a probiotic，is negatively linked to IBD, obesity, and T2DM. The aim of this study was to comprehensively assess the research status of Akkermansia muciniphila over the past decade and explore the relationships between this bacterium and various health-related aspects.: Tools VOSviewer, Bibliometrix, and CiteSpace were used to analyze various aspects including publication metrics, contributors, institutions, geography, journals, funding, and keywords. Results: Over the past decade, research on Akkermansia muciniphila has demonstrated a consistent annual growth in the number of publications, with a notable peak in 2021. China led in the number of publications, totaling 151, whereas the United States exhibited a higher centrality value. Among the 820 institutions involved in the research, the University of California (from the United States) and the Chinese Academy of Sciences (from China) occupied central positions. Willem M. De Vos ranked at the top, with 12 publications and 1,108 citations. The journal GUT, which had 5,125 citations and an Impact Factor of 23.0 in 2024, was the most highly cited. The most cited articles deepened the understanding of the bacterium's impact on human health, spanning from basic research to translational medicine. Thirty-nine high-frequency keywords were grouped into five clusters, illustrating Akkermansia muciniphila's associations with metabolic diseases, chronic kidney disease, the gut-brain axis, intestinal inflammation, and Bacteroidetes-Firmicutes shifts.Given Akkermansia muciniphila's anti-inflammatory and gut-barrierstrengthening properties, it holds promise as a therapeutic for obesity, metabolic disorders, and inflammatory conditions. Therefore, future research should explore its potential further by conducting clinical trials, elucidating its mechanisms of action, and investigating its efficacy and safety in diverse patient populations.

    Keywords: Akkermansia muciniphila, Bibliometrics, Gut Microbiota, gut-brain axis, 45 metabolic disorder

    Received: 22 Aug 2024; Accepted: 21 Jan 2025.

    Copyright: © 2025 Gao, Cheng, Chen, Tang, Li and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Guankui Du, Hainan Medical University, Haikou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.