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ORIGINAL RESEARCH article

Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1481213

Association of Lung Health and Cardiovascular health(Life's Essential 8)

Provisionally accepted
Wanjia Zhang Wanjia Zhang Menglong Zou Menglong Zou Junyao Liang Junyao Liang Dexu Zhang Dexu Zhang Man Zhou Man Zhou Hui Feng Hui Feng Chusen Tang Chusen Tang Jie Xiao Jie Xiao Yin Xu Yin Xu *
  • The First Hospital of Hunan University of Chinese Medicine, Changsha, China

The final, formatted version of the article will be published soon.

    Background: Cardiorespiratory health issues often intersect. This study explored the relationship between lung health and the recently updated Cardiovascular Health Measure (Life's Essential 8).: Data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES) were analyzed. Three cohorts were included: lung disease in the Main cohort (N=9,772), lung function in the Spirometry sub-cohort (N=3,896), and respiratory symptoms in the Respiratory Symptoms sub-cohort(Age>40) (N=3,449).LE8 scores were used as both continuous and categorical variables (0-49, 50-79, 80-100). Weighted multivariate regression analyses examined the correlations between LE8 and lung health, and weighted restricted cubic spline (RCS) regression analyzed potential nonlinear relationships. Subgroup analysis was conducted to verify stability.Results: Overall lung health was better in the high LE8 group than in the low LE8 group. In the fully adjusted model, the high LE8 group had significantly lower odds of asthma (OR = 0.42; 95% CI = 0.29, 0.59) and chronic bronchitis (OR = 0.27; 95% CI = 0.15, 0.49) compared to the low LE8 group. Regarding lung function, each 10-point increase in LE8 was associated with an increase of 50 ml in FEV1 (Beta = 50; 95% CI = 32, 67) and 56 ml in FVC (Beta = 56; 95% CI = 32, 79). Among middle-aged and older adults (age > 40), the high LE8 group had significantly lower odds of respiratory symptoms, including cough (OR = 0.23; 95% CI = 0.12, 0.46), phlegm (OR = 0.42; 95% CI = 0.19, 0.90), and wheezing (OR = 0.29; 95% CI = 0.15, 0.54).RCS analyses demonstrated a nonlinear negative correlation between LE8 and cough, sputum, and wheeze. Subgroup and sensitivity analysis suggested stability.2 Conclusion: LE8 scores are positively associated with lung health in the US population. These findings provide a valuable reference for maintaining overall cardiorespiratory health.

    Keywords: Cardiovascular health, Lung Health, Life's Essential 8, NHANES, Cross-sectional study

    Received: 20 Aug 2024; Accepted: 15 Jan 2025.

    Copyright: © 2025 Zhang, Zou, Liang, Zhang, Zhou, Feng, Tang, Xiao and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yin Xu, The First Hospital of Hunan University of Chinese Medicine, Changsha, China

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