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SYSTEMATIC REVIEW article
Front. Med.
Sec. Nephrology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1473818
Efficacy of antioxidant intervention and exercise intervention for Lipid Peroxidation in Dialysis Patients: A Meta-Analysis
Provisionally accepted- The Second Hospital of Jilin University, Jilin University, Changchun, China
BackgroundLipid peroxidation is a major factor known to contribute to occurrence of cardiovascular events in dialysis patients. This study aims to investigate whether antioxidant interventions can improve lipid peroxidation damage in dialysis patients.MethodsA comprehensive search in PubMed, Embase, and the Cochrane Library was conducted to identify eligible randomized controlled trials (RCTs) up to June 2024. Endpoints of interest included biomarkers related to Lipid peroxidation. The results from eligible studies were performed using RevMan 5.3 and Stata17.0 software. ResultsA total of 29 RCTs were included, involving 8 interventions such as vitamin C supplementation, vitamin E supplementation, vitamin E-coated dialyzer, ω-fatty acid supplementation, curcumin supplementation, pomegranate juice supplementation, exercise intervention, and multiple antioxidant interventions. Outcome indicators included malondialdehyde (MDA) and oxidized low-density lipoprotein (Ox-LDL). The meta-analysis revealed that Vitamin E supplementation caused significant reductions in MDA (P=0.01). Treatment with Vitamin E-coated dialyzer markedly decreased MDA levels (P<0.0001). Juice supplementation significantly reduced Ox-LDL levels (P<0.0001). Curcumin supplementation significantly reduced Ox-LDL levels (P=0.03). Exercise intervention decreased MDA levels (P<0.0001). Multiple antioxidant interventions significantly decreased MDA (P=0.01).ConclusionSupplementation of vitamin E, vitamin E-coated dialyzer treatment, curcumin, exercise intervention, and multiple antioxidant interventions can effectively reduce the level of lipid peroxidation biomarkers in dialysis patients.
Keywords: Lipid Peroxidation, hemodialysis, Peritoneal Dialysis, antioxidant intervention, Malondialdehyde
Received: 31 Jul 2024; Accepted: 24 Feb 2025.
Copyright: © 2025 Yu, Liu, Li, Ni, Xinyang and Cui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wenpeng Cui, The Second Hospital of Jilin University, Jilin University, Changchun, China
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