The Visual Analysis of Hot Topics and Trends in the Research on Contrast Agent Extravasation in Medical Imaging Examinations: A Bibliometric Study Using CiteSpace and VOSviewer

Yun Liu ¹ Yonghai Dong ² Wenfang Zhou ² Juhong Yu ^3*

• ¹ Jiangxi Provincial People's Hospital (the first affiliated hospital of Nanchang Medical college), Nanchang, China
• ² Jiangxi Provincial Center for Disease Control and Prevention, Nanchang, Jiangxi Province, China
• ³ Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang Medical College), Jiangxi Provincial People's Hospital, Nanchang, China

Purpose: This study visualizes the global research dynamics on contrast agent extravasation in medical imaging examinations using a knowledge map, revealing the research directions, hot topics, trends, and frontiers in this field.Method: Utilizing CiteSpace and VOSviewer software with the Web of Science Core Collection database as the data source, a bibliometric analysis was conducted on relevant studies of contrast agent extravasation in medical imaging examinations. Analysis was performed on aspects such as yearly publication volume, country/institution distribution, authorship, co-citation documents, keywords, etc., leading to the creation of visualizations.Results: A total of 4,635 articles were included in the study, with the first relevant research report appearing in 1950. The yearly publication and citation volumes showed an overall increasing trend. Research in this field was predominantly concentrated in the USA, accounting for approximately one-third of the global publication output. University of California System was the top institution in terms of publication volume. The top 5 high-frequency keywords were “magnetic resonance imaging,” “computed tomography,” “management,” “diagnosis,” “contrast agent.” Cluster analysis of keywords revealed three main clusters: “contrast,” “fluorescein angiography,” and “focused ultrasound,” showing good continuity over time. The keyword burst analysis identified “gd dtpa” as the highest burst value at 20.51. The emergence of keywords shifted over time. At present, the keywords that are still in an emerging state are “multimodal imaging,” “case report,” and “leakage.”Conclusion: More scholars are dedicating efforts to research on contrast agent extravasation in medical imaging examinations. “Multimodal imaging” will be key research focuses in the foreseeable future. Contrast agent extravasation remains a substantial challenge in medical imaging examinations with high research value.