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ORIGINAL RESEARCH article

Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1467771

Analysis of clinical characteristics and risk factors for patients with heat stroke in western China in 2022: a multicenter retrospective study

Provisionally accepted
Xin Zheng Xin Zheng 1Yuchun Gao Yuchun Gao 1*Qinli Xie Qinli Xie 2*Qiulan Chen Qiulan Chen 3*Chuan Guo Chuan Guo 4*Qionglan Dong Qionglan Dong 5*Jin Tang Jin Tang 6*Jun Luo Jun Luo 7*Ying Ge Ying Ge 8Jian He Jian He 9*Xiaolin Hou Xiaolin Hou 10*Zhou Guanghong Zhou Guanghong 1Yuan Chen Yuan Chen 2*Haiquan Cao Haiquan Cao 3*Jiujia Xiao Jiujia Xiao 4*An Lan An Lan 5*Yonghong Zeng Yonghong Zeng 10*Jing Huang Jing Huang 9*Huaicong Long Huaicong Long 1*
  • 1 Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
  • 2 Chongqing Emergency Medical Center, Chongqing, China
  • 3 Nanchong Hospital of Beijing Anzhen Hospital, China, China
  • 4 First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China
  • 5 Mianyang Third People's Hospital, Mianyang, China
  • 6 Affiliated Hospital and Clinical Medical College of Chengdu University, Chengdu, Sichuan Province, China
  • 7 Xuanhan County People 's Hospital, DaZhou, China
  • 8 Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China
  • 9 Chongqing General Hospital, Chongqing, Chongqing, China
  • 10 Zigong First People's Hospital, Zigong, Sichuan Province, China

The final, formatted version of the article will be published soon.

    To analyzed the clinical characteristics and treatment modalities of heat stroke (HS) and to identify risk factors for a poor prognosis of HS and provide reference suggestions for its treatment and prevention.We enrolled a total of 247 patients, with hypertension, diabetes, and psychosis being the top three comorbidities associated with HS.The incidence of HS was higher among males and older individuals. Compared to the control group, the poor prognosis group experienced higher temperatures, a higher incidence of cerebral edema, and gastrointestinal bleeding (all P < 0.05). The poor prognosis group had significantly higher blood pH, HCO3-, Lac, Scr, AST, ALT, DBIL, CKMB, PT, DD, and PLT (all P < 0.05). Furthermore, logistic regression analysis revealed that Lac, Scr, and APACHE II were risk factors for poor prognosis (P < 0.05). The AUC values for the combined diagnostic model were 0.848 (95% CI: 0.781-0.914). Male morbidity, the number of patients with combined hypertension, the prognosis, and the APACHE II score and ALT level were all greater (P<0.05) in the CHS group. The Kaplan-Meier analysis revealed that the CHS group had a significantly higher mortality rate than the EHS group.A high incidence of hypertension, diabetes, psychosis, men, and older persons may be associated with HS. HS patients with high blood cell counts, impaired coagulation, liver and kidney diseases, and those with a specific type of CHS may face a poor prognosis. In patients with heart failure, APACHE II, Lac, and Scr were independent risk factors for a poor prognosis.

    Keywords: Heat Stroke, prognosis, Clinical Characteristics, risk factor, Treatment

    Received: 20 Jul 2024; Accepted: 08 Jan 2025.

    Copyright: © 2025 Zheng, Gao, Xie, Chen, Guo, Dong, Tang, Luo, Ge, He, Hou, Guanghong, Chen, Cao, Xiao, Lan, Zeng, Huang and Long. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuchun Gao, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
    Qinli Xie, Chongqing Emergency Medical Center, Chongqing, China
    Qiulan Chen, Nanchong Hospital of Beijing Anzhen Hospital, China, China
    Chuan Guo, First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China
    Qionglan Dong, Mianyang Third People's Hospital, Mianyang, China
    Jin Tang, Affiliated Hospital and Clinical Medical College of Chengdu University, Chengdu, 610081, Sichuan Province, China
    Jun Luo, Xuanhan County People 's Hospital, DaZhou, 636150, China
    Jian He, Chongqing General Hospital, Chongqing, 400081, Chongqing, China
    Xiaolin Hou, Zigong First People's Hospital, Zigong, Sichuan Province, China
    Yuan Chen, Chongqing Emergency Medical Center, Chongqing, China
    Haiquan Cao, Nanchong Hospital of Beijing Anzhen Hospital, China, China
    Jiujia Xiao, First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China
    An Lan, Mianyang Third People's Hospital, Mianyang, China
    Yonghong Zeng, Zigong First People's Hospital, Zigong, Sichuan Province, China
    Jing Huang, Chongqing General Hospital, Chongqing, 400081, Chongqing, China
    Huaicong Long, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China

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