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ORIGINAL RESEARCH article

Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1460956
This article is part of the Research Topic Advancements in Multimodal Data Analysis for Lung Tumor Diagnosis View all 10 articles

Gene Mutation in Diabetic Patients with Lung Adenocarcinoma: A Real-World Retrospective Cohort Study

Provisionally accepted
Lei Yang Lei Yang 1*Yang Hong Yang Hong 1Tingting Zeng Tingting Zeng 1Hongmei Yue Hongmei Yue 2De Peng Jiang De Peng Jiang 1*
  • 1 Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
  • 2 First Hospital of Lanzhou University, Lanzhou, Gansu Province, China

The final, formatted version of the article will be published soon.

    The occurrence of lung cancer is closely related to diabetes, but it is not clear whether diabetes will affect the genetic mutations in lung cancer, so we will compare the genetic mutations in lung adenocarcinoma(ADC) patients with and without diabetes. Methods: We included 279 lung adenocarcinoma patients (143 with diabetes and 136 without diabetes) diagnosed at the Second Affiliated Hospital of Chongqing Medical University from 2016 to 2023, and analyzed the clinical characteristics and genetic mutation results of all participants.Results: In contrast to ADC patients without diabetes, ADC patients with diabetes had lower overall gene mutation rate (49.7% vs. 62.5%, p = 0.031). Female ADC patients had higher total gene mutation rate and EGFR gene mutation rate than male ADC patients(47.3% vs.66.1%, p = 0.002, 27.6% vs. 58.3%, p < 0.001, respective) , but the TP53 gene mutation rate is lower(8.6% vs.2.4%, p = 0.027). ADC patients without smoking history had higher gene mutation rate and EGFR gene mutation rate than ADC patients with smoking history(62.1% vs. 44.3%, p = 0.004, 51.6% vs 22.7%, p < 0.001, respective), but the KRAS gene mutation rate is lower(4.4% vs. 14.4%, p = 0.003). ADC patients with drinking history had lower EGFR gene mutation rate than ADC patients without drinking history(31.0% vs. 47.5%, p = 0.007), but the KRAS gene mutation rate is higher(14.0% vs. 4.5%, p = 0.005). Through univariate and multivariate linear regression analyses, we found that female, no smoking history, phase II and IV of tumor stage was connected to gene mutation.This real-world retrospective study suggests that Lung adenocarcinoma patients with diabetes may be a lower chance of developing genetic mutations, and gender, smoking history, tumor stage maybe associated to gene mutation.

    Keywords: Lung Adenocarcinoma, Gene mutations, diabetes, Smorking, Drinking

    Received: 07 Jul 2024; Accepted: 03 Jan 2025.

    Copyright: © 2025 Yang, Hong, Zeng, Yue and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Lei Yang, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
    De Peng Jiang, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

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