Associations Between Asthma and Life's Essential 8: A Cross-sectional Study

jiao xu Jianlei Tang ^*

• Changzhou Wujin People's Hospital, Changning, China

Background: Asthma is a serious respiratory disease attributed to multiple factors. The Life's Essential 8 (LE8) is a tool introduced by the American Heart Association in order to improve and maintain healthy cardiovascular system. However, the correlation between the components of LE8 and asthma is not fully understood. We hypothesized that LE8 is a protective factor against asthma. Materials and Methods: Multiple logistic regression analysis, restricted cubic spline (RCS ) analysis and subgroup analysis were used to analyze the data collected from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2018. Results: Totally, 3,360 participants suffering asthma were enrolled. With all confounders controlled, LE8 scores were negatively correlated with asthma prevalence (odds ratio (OR) for per 10-point increment, 0.85 [95% confidence interval (CI), 0.82-0.88]). When comparing the moderate and high LE8 scores to the low scores, the adjusted OR (95% CI) for asthma risk were 0.59 (0.51, 0.68), 0.48 (0.39,0.58), respectively. The nonlinear correlations were shown between LE8 scores and asthma (p nonlinear=0.01), between the health factors scores and asthma (p nonlinear=0.01), but there was a linear dose-response correlation between the health behavior score and asthma (p nonlinear=0.30).Subgroup analysis showed no significant interaction effect (p＞0.05), except in sex and drinking status subgroups (p for interaction=0.02). Conclusion: Asthma shows association with components of LE8, which should be paid more attention and may be helpful to decrease the asthma prevalence.