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ORIGINAL RESEARCH article

Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1446782

Dose-response relationship between Life's Essential 8 score and COPD risk: the NHANES cohort study 2007-2018

Provisionally accepted
Qian Huang Qian Huang 1Quan Yuan Quan Yuan 2Wenqiang Li Wenqiang Li 2Xiaoyu He Xiaoyu He 3*Qian He Qian He 4*Zhiping Deng Zhiping Deng 2*
  • 1 Dazhou Third People's Hospital, Dazhuo, China
  • 2 Zigong First People's Hospital, Zigong, China
  • 3 North Sichuan Medical College, Nanchong, Sichuan Province, China
  • 4 West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Objective: This Our study aims to discuss the dose-response relationship between the Life's Essential 8 (LE8) score and chronic obstructive pulmonary disease (COPD).We screened data from the National Health and Nutrition Examination Survey (NHANES) database for the years 2007-2018. Logistics regression analysis and subgroup analysis were used to explore the relationship between cardiovascular health (CVH) and COPD based on the LE8 score.Additionally, restricted cubic spline (RCS) plots were drawn to visually display the dose-response relationship.Results: A total of 12,517 participants were included, of which 835 had COPD. After multivariable adjustment, the LE8 score was found to be linearly and inversely associated with the risk of developing COPD. A similar relationship was observed in the scores for health behavior factors, whereas the relationship was weaker for health factors. The RCS plots visually demonstrated the aforementioned dose-response relationship. Moreover, subgroup analyses showed that this relationship remained robust across different groups. Conclusion: LE8 scores are inversely and linearly associated with the risk of developing COPD.Higher LE8 scores can reduce the risk of developing COPD in individuals over 40 years old, especially concerning health behavior factors.

    Keywords: CVH, COPD, Dose-response relationship, LE8 Score, Health behavioural factors, Health factors

    Received: 10 Jun 2024; Accepted: 02 Jan 2025.

    Copyright: © 2025 Huang, Yuan, Li, He, He and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiaoyu He, North Sichuan Medical College, Nanchong, Sichuan Province, China
    Qian He, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China
    Zhiping Deng, Zigong First People's Hospital, Zigong, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.