Efficacy of acupuncture for Stroke-Associated Pneumonia: A systematic review and metaanalysis

Kaihan Su ¹ Wang Xiaoyu ¹ Shiying Zhang ^1* Jiantong Wu ^1* Yuqi Chen ^2* Lianjun Yin ^3* Huanan Li ¹ Jingui Wang ^1*

• ¹ First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, China
• ² Department of Acupuncture, Traditional Chinese Medicine Hospital of Kunshan, kunshan, China
• ³ Recovery Unit, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China

This study aims to systematically evaluate the efficacy of acupuncture on Stroke-Associated Pneumonia (SAP).Methods: English and Chinese databases were searched from their inception until 15 March 2024 to collect randomized controlled trials (RCTs). The risk of bias was assessed using Cochrane collaboration tools. RevMan 5.4.0 software was used to analyse the included studies, and the Grades of Recommendations, Assessment, Development, and Evaluation (GRADE) assessment was used to evaluate the quality of the study outcomes.Results: 16 studies involving 1125 patients were included in this meta analysis. Compared with the control group, the results showed that acupuncture significantly improved the effective rate [RR = 1.20, 95% CI (1.13, 1.27), P <0.00001] and reduced the level of white blood cells (WBC) [MD = -6.52, 95% CI (-8.31, -4.73), P < 0.00001], C reactive protein (CRP) [MD = -6.50, 95% CI (-9.97, -3.03), P = 0.0002], neutrophil percentage (Neu%) [MD = -6.66, 95% CI (-8.96, -4.36), P < 0.00001], and procalcitonin (PCT) [MD = -0.81, 95% CI (-1.21, -0.40), P < 0.0001]. Additionally, acupuncture 2 therapy shortened the duration of coughing [MD = -3.22, 95% CI (-4.73, -1.72), P < 0.0001], duration until disappearance of rales [MD = -3.99, 95% CI (-6.44, -1.54), P = 0.001], and duration of antibiotic use [MD = -4.51, 95% CI (-5.46, -3.57), P < 0.00001]. It also reduced the Clinical Pulmonary Infection Score (CPIS) [MD = -1.71, 95% CI (-2.71, -0.71), P = 0.0008] and National Institute of Health Stroke Scale (NIHSS) [MD = -3.93, 95% CI (-5.78, -2.09), P < 0.00001]. Moreover, acupuncture therapy increased the Forced Vital Capacity (FVC) [MD = 0.46, 95% CI (0.02, 0.89), P = 0.04] and Forced Expiratory Volume in One Second (FEV1) [MD = 0.49, 95% CI (0.14, 0.84), P = 0.006].This study found that acupuncture has a positive effect in treating SAP. However, owing to the low-quality evidence, more rigorous studies are needed in the coming years to confirm these findings.