AUTHOR=Krebs Emanuel , Bubela Tania , McPhail Melanie , McCabe Christopher , Regier Dean A. TITLE=Putting the substance in substantial evidence: an evidence-based approach to flexible drug regulation JOURNAL=Frontiers in Medicine VOLUME=12 YEAR=2025 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1337890 DOI=10.3389/fmed.2025.1337890 ISSN=2296-858X