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PERSPECTIVE article

Front. Med.
Sec. Ophthalmology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1531670
This article is part of the Research Topic Women in Science: Ophthalmology 2024 View all articles

Therapeutic Benefits of Glycerol in Dry Eye Disease

Provisionally accepted
Victoria Ronderos Victoria Ronderos Wendy B Bollag Wendy B Bollag *
  • Medical College of Georgia, Augusta University, Augusta, Georgia, United States

The final, formatted version of the article will be published soon.

    Dry eye disease (DED) is one of the most commonly diagnosed eye disorders, with a prevalence ranging from 5% to 50%, depending on the geographic location. DED is a multifactorial disorder of the tears and ocular surface, which results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is also accompanied by increased osmolarity of the tear film and inflammation of the surface of the eye. Multiple therapeutic agents have been uesed to treat DED, with glycerol emerging as a promising component of ophthalmic preparations, due to its humectant, lubricant, demulcent, and osmoprotective properties. This review aims to evaluate the current evidence concerning the therapeutic benefits of glycerol in managing DED, focusing on its possible mechanisms of action, clinical efficacy, and potential advantages over other treatments.

    Keywords: Cornea, Dry eye disease (DED), Glycerin, Glycerol, Inflammation, Phosphatidylglycerol

    Received: 20 Nov 2024; Accepted: 26 Dec 2024.

    Copyright: © 2024 Ronderos and Bollag. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wendy B Bollag, Medical College of Georgia, Augusta University, Augusta, Georgia, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.