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ORIGINAL RESEARCH article

Front. Med.
Sec. Geriatric Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1523581
This article is part of the Research Topic Inflammation in the Elderly: Therapeutic Drugs and Strategies View all 6 articles

The change of inflammatory markers may predict long-term major adverse cardiovascular events in elderly patients with coronary heart disease: a retrospective cohort study

Provisionally accepted
Li He Li He *Si-si Chen Si-si Chen Xuan Zhu Xuan Zhu Fang He Fang He
  • Wuhan Fourth Hospital, Wuhan, China

The final, formatted version of the article will be published soon.

    Background: At present, the relationship among inflammatory markers [monocytes/HDL-c (MHR), neutrophils/HDL-c (NHR) and lymphocytes/HDL-c (LHR)] and long-term prognosis of coronary heart disease (CHD) is still unclear.Therefore, this study explores the relationship between inflammatory indicators and the risk of long-term major adverse cardiovascular events (MACE) in elderly patients with CHD.Methods: A retrospective analysis was conducted on 208 elderly patients who underwent CAG at Wuhan Fourth Hospital from August 2022 to August 2023. They were divided into the CHD group (N=116) and control group (N=92). Patients in the CHD group were followed up for one year and divided into the MACE group (N=36) and the non-MACE group (N=80) according to whether MACE occurred.In elderly patients, logistic regression analysis shows that MHR is an independent risk factor for CHD (OR=3.050, 95% CI 1.318-1.772). ROC curve analysis found that MHR (AUC=0.865, 95% CI 0.811-0.919, P<0.001) is higher than NHR and LHR. In patients with CHD, the spearman analysis show that MHR is positively correlated with GS score (R=0.266, P=0.004). The logistic regression analysis found that MHR is independent risk factors for MACE (OR=6.048, 95% CI 1.224-1.941, P=0.002). ROC analysis showed that the critical value of MHR to predict MACE was 0.651, the sensitivity of 58.3% and specificity of 90.0% could predict MACE, and the AUC was 0.793 (95% CI 0.702-0.884, P<0.001) is higher than LHR.In elderly patients, MHR is an independent predictor of CHD and long-term MACE and is positively correlated with the severity of coronary artery lesions.

    Keywords: Monocytes, High-density lipoprotein cholesterol, coronary heart disease, elderly patients, monocyte/HDL

    Received: 06 Nov 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 He, Chen, Zhu and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Li He, Wuhan Fourth Hospital, Wuhan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.