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ORIGINAL RESEARCH article

Front. Med.
Sec. Geriatric Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1518222

Construction of Geriatric Hypoalbuminemia Predicting Model for Hypoalbuminemia Patients with and without Pneumonia and Explainability Analysis

Provisionally accepted

    The final, formatted version of the article will be published soon.

      Background and objectives: Pneumonia portrays a critical health concern in geriatrics. Geriatric pneumonia can lead to changes on other complications, in which hypoalbuminemia is a common complication. However, few studies have looked at the impact of pneumonia on the course of hypoalbuminemia and predicting. This study aims to predicting hypoalbuminemia in geriatric pneumonia and non-pneumonia patients and exploring the clinical difference between the two groups.: This retrospective study enrolled 42 pneumonia patients group and 76 nonpneumonia patients group. The indicators difference of different groups were analyzed, then a mutual information-grey relational coefficient gradual fusion model was constructed to predict hypoalbuminemia in the future by the indicators of vital signs, N-Terminal Pro-Brain Natriuretic Peptide, blood routine examination and urine routine examination at admission. Through the sensitivity analysis of model, we analysed the important of four examines in patients with and without pneumonia.The predicted accuracy of our gradual fusion model was 0.954, which improve the prediction accuracy by nearly 17.6% compared with the classical machine learning method. The AUC of gradual fusion model was 0.96 and 0.9 in hypoalbuminemia patients with and without pneumonia. The sensitivity analysis of gradual fusion model showed blood routine examine was most important to predict hypoalbuminemia in patients with pneumonia, while urine routine examine was most important to predict hypoalbuminemia in non-pneumonia patients.The changes in the blood of patients with hypoalbuminemia combined with pneumonia were more significant than that of patients with hypoalbuminemia alone, which was characterized by abnormal excretion due to low protein. We suggested doctors should pay more attention to blood routine results when preventing hypoalbuminemia in patients with pneumonia and pay more attention to urine routine examine results when preventing hypoalbuminemia in patients without pneumonia.

      Keywords: geriatric, Pneumonia, Hypoalbuminemia, statistical analysis, machine learning prediction, Gradual fusion prediction

      Received: 28 Oct 2024; Accepted: 10 Dec 2024.

      Copyright: © 2024 . This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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