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CASE REPORT article

Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1513771

Case Report: A uremic patient with intracranial infection caused by Ralstonia mannitolilytica, which was almost misdiagnosed as demyelinating disease, had special imaging features

Provisionally accepted
HanXin Kong HanXin Kong *Hao Ying Hao Ying *Jianhong Yang Jianhong Yang
  • Department of Neurology, Ningbo First Hospital, Ningbo, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    Ralstonia mannitolilytica is a very rare pathogen that causes intracranial infection. It is commonly found in immunocompromised patients and is resistant to multiple antibiotics. In this case report, we present a case of human central nervous system infection caused by Ralstonia mannitolilytica, which was initially misdiagnosed as demyelinating disease due to the specific imaging findings. This case had concurrent uremia and a good response to meropenem under continuous peritoneal dialysis. The diagnosis is mainly based on cerebrospinal fluid analysis and targeted genetic testing by next generation sequencing (NGS). However, the patient had a poor prognosis due to uncontrollable gastrointestinal bleeding and related complications during long-term bed rest. We hope that this case will attract more attention and provide relevant reference for the diagnosis and treatment of other similar patients.

    Keywords: Ralstonia mannitolilytica, Next generation sequencing (NGS), Intracranial infection, Uremic, Peritoneal Dialysis

    Received: 19 Oct 2024; Accepted: 20 Dec 2024.

    Copyright: © 2024 Kong, Ying and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    HanXin Kong, Department of Neurology, Ningbo First Hospital, Ningbo, 315010, Zhejiang Province, China
    Hao Ying, Department of Neurology, Ningbo First Hospital, Ningbo, 315010, Zhejiang Province, China

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