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REVIEW article

Front. Med.
Sec. Pathology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1512916
This article is part of the Research Topic Glycolipid Metabolism Disorders in Cerebrovascular and Cardiovascular Diseases: Advanced Insights Into Pathology, Pathophysiology and Treatment View all articles

Unraveling the cGAS/STING Signalling Mechanism: Impact on Glycerolipid Metabolism and Diseases

Provisionally accepted
Jie Su Jie Su 1,2Fuyu Cheng Fuyu Cheng 1,3*Wei Yuan Wei Yuan 1*
  • 1 Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
  • 2 King's College London, London, England, United Kingdom
  • 3 Queen Mary University of London, London, United Kingdom

The final, formatted version of the article will be published soon.

    The cyclic GMP-AMP synthase (cGAS) and its downstream effector, the stimulator of interferon genes (STING), are crucial components of the innate immune response, traditionally recognised for their role in detecting cytosolic DNA from pathogens and damaged host cells.However, recent research indicates that the cGAS-STING pathway also significantly impacts metabolic processes, particularly glycerolipid metabolism. Glycerolipids are essential for energy storage and cellular membrane integrity, and their dysregulation is linked to metabolic disorders such as obesity, insulin resistance, and non-alcoholic fatty liver disease (NAFLD).Both cGAS and STING are expressed in various metabolic tissues, suggesting a potential role in lipid homeostasis. Chronic activation of the cGAS-STING pathway may promote inflammatory states that exacerbate insulin resistance and lipid accumulation, forming a feedback loop of metabolic dysfunction. This review explores the emerging relationship between cGAS/STING signalling and glycerolipid metabolism, discussing the mechanisms through which this pathway influences lipid regulation and the potential for therapeutic interventions. By integrating insights from immunology and metabolism, we aim to provide a comprehensive understanding of how the cGAS-STING axis may serve as a novel target for addressing metabolic disorders and enhancing metabolic health outcomes.

    Keywords: cGAS/STING pathway, Inflammation, immune respnse, Glycerolipid metabolism, cardiovasccular disease

    Received: 17 Oct 2024; Accepted: 11 Nov 2024.

    Copyright: © 2024 Su, Cheng and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Fuyu Cheng, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
    Wei Yuan, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.