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ORIGINAL RESEARCH article

Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1510997

Association between Red Cell Distribution Width and 30-day mortality in patients with Sepsis-Associated Liver Injury: A Retrospective Cohort Study

Provisionally accepted
Ting Ao Ting Ao Yingxiu Huang Yingxiu Huang Peng Zhen Peng Zhen *Ming Hu Ming Hu *
  • Beijing Luhe Hospital, Capital Medical University, Beijing, China

The final, formatted version of the article will be published soon.

    Background: Sepsis-associated liver injury (SALI) is a critical component of sepsis-induced multiple organ dysfunction with high mortality. Identifying biomarkers for risk stratification is essential. Red cell distribution width (RDW), indicating variation in red blood cell volume, has been linked to adverse outcomes in various diseases. This study aimed to evaluate the association between RDW and 30-day mortality in SALI patients. Methods: A retrospective cohort study was conducted using data from the Medical Information Mart for Intensive Care-IV database. Patients admitted to the intensive care unit (ICU) with SALI were included. RDW was recorded within the initial 24 hours. The primary outcome was 30-day mortality. A multivariable Cox regression analysis was performed to examine the relationship between RDW and mortality. Results: Among 529 SALI patients (mean age 68.7 years, 61.8% male), 46.1% had RDW >15.5%. The 30-day mortality rate was 35.5%. RDW was significantly higher in non-survivors compared to survivors (17.2±3.0 vs. 15.4±2.3, P < 0.001). Cox regression identified RDW as an independent risk factor for 30-day mortality (HR 1.14, 95% CI 1.09 to 1.19, P < 0.001). Subgroup analyses demonstrated that the findings were consistent across the various groups. Conclusion: Elevated RDW is independently associated with higher 30-day mortality in patients with SALI, suggesting its potential role in risk stratification and clinical management.

    Keywords: Sepsis-associated liver injury, Red cell distribution width, 30-day mortality, Critical Illness, Sepsis

    Received: 14 Oct 2024; Accepted: 29 Nov 2024.

    Copyright: © 2024 Ao, Huang, Zhen and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Peng Zhen, Beijing Luhe Hospital, Capital Medical University, Beijing, China
    Ming Hu, Beijing Luhe Hospital, Capital Medical University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.