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ORIGINAL RESEARCH article

Front. Med.
Sec. Ophthalmology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1507971
This article is part of the Research Topic Imaging in the Diagnosis and Treatment of Eye Diseases View all 10 articles

The amplitude of low frequency fluctuation and spontaneous brain activity alterations in age-related macular degeneration

Provisionally accepted
Yan-yan Zhang Yan-yan Zhang 1Ling Qian Ling Qian 2*Jinyu Hu Jinyu Hu 2*Sanhua Xu Sanhua Xu 2Min Kang Min Kang 2Hong Wei Hong Wei 2Jie Zou Jie Zou 2Quanyong Yi Quanyong Yi 1*Gan Tan Gan Tan 3*YI SHAO YI SHAO 1,4*
  • 1 Ningbo Eye Hospital, Ningbo, Zhejiang Province, China
  • 2 Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
  • 3 Department of Ophthalmology, the First Affliated Hospital of University of South China, Hunan Center of National Ocular Disease Clinical Research Center, Hengyang, China
  • 4 Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Research Ophthalmology Cetre, Nanchang, China

The final, formatted version of the article will be published soon.

    Background: Wet age-related macular degeneration (wAMD) is a vision-threatening eye disease worldwide. The amplitude of low-frequency fluctuation (ALFF) method was used to observe changes in spontaneous brain activity, which may help to investigate the underlying pathological mechanism of AMD.Methods: Eighteen patients with wAMD and 18 age-and gender-matched healthy controls (HCs) were recruited. The ALFF method was used on each subject and mean ALFF values were compared between groups. The receiver operating characteristic (ROC) curve was used to compare the two groups.Results: ALFF values in the temporal lobe and limbic lobe/parahippocampal gyrus were significantly higher than controls, while values in the postcentral gyrus were significantly lower. The under the curve of the ROC (AUC) of the three regions shows high accuracy of the diagnosis.The abnormal spontaneous brain activity of patients with AMD suggests scope for the use of ALFF in the diagnosis or prognosis in AMD.

    Keywords: the amplitude of low-frequency fluctuation, age-related macular degeneration, spontaneous brain activity, functional magnetic resonance imaging, resting brain activity‎

    Received: 08 Oct 2024; Accepted: 17 Dec 2024.

    Copyright: © 2024 Zhang, Qian, Hu, Xu, Kang, Wei, Zou, Yi, Tan and SHAO. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Ling Qian, Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China
    Jinyu Hu, Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China
    Quanyong Yi, Ningbo Eye Hospital, Ningbo, Zhejiang Province, China
    Gan Tan, Department of Ophthalmology, the First Affliated Hospital of University of South China, Hunan Center of National Ocular Disease Clinical Research Center, Hengyang, China
    YI SHAO, Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Research Ophthalmology Cetre, Nanchang, China

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