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CASE REPORT article

Front. Med.
Sec. Dermatology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1507524

Adalimumab induced psoriasis in crohn's disease and treatment with ustekinumab: Case report and special histopathological findings

Provisionally accepted
Fang Qiu Fang Qiu 1Weiquan Chen Weiquan Chen 2Ying Zhou Ying Zhou 1*
  • 1 Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China
  • 2 Dongguan Maternal and Child Health Hospital, Guangdong, China

The final, formatted version of the article will be published soon.

    This case report presents an instance of Tumor Necrosis Factor-α Inhibitor-induced psoriasis (TNFiIP), also known as paradoxical psoriasis, in a 30-year-old male with fistulizing Crohn's disease. The patient developed extensive erythematous and scaly lesions on the palms, lower limbs, ankles, and soles after four months of adalimumab monotherapy. Histopathological analysis revealed a pattern of psoriasiform dermatitis with notable dermal neutrophil and eosinophil infiltration, distinguishing TNFiIP from idiopathic psoriasis. The patient's condition significantly improved following the transition from adalimumab to ustekinumab, which highlights the importance of alternative therapeutic strategies for patients who exhibit paradoxical reactions to TNF-α inhibitors.

    Keywords: TNF-α inhibitor induced psoriasis, Adalimumab, Crohn's disease, Ustekinumab, case report

    Received: 07 Oct 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Qiu, Chen and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ying Zhou, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China

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