Corrigendum: Patients with microscopic colitis have altered levels of inhibitory and stimulatory biomarkers in colon biopsies and sera compared to non-inflamed controls

A Corrigendum on
Patients with microscopic colitis have altered levels of inhibitory and stimulatory biomarkers in colon biopsies and sera compared to non-inflamed controls

by Lushnikova, A., Bohr, J., Wickbom, A., Münch, A., Sjöberg, K., Hultgren, O., Wirén, A., and Hultgren Hörnquist, E. (2021). Front. Med. 8:727412. doi: 10.3389/fmed.2021.727412

In the published article, reference Rajabian et al. (2019) (54) was not cited in the article. The citation has now been inserted in the Discussion, paragraph 9, and should read:

“PD-1 is an inhibitory receptor expressed on activated T cells that has been reported to be upregulated in IBD (19, 52). In accordance with this, we also found increased expression in the colon of MC and UC patients with active disease. The opposite was seen in serum where levels of PD-1 were decreased. Reviews of the functions of soluble PD-1 (sPD-1) describe the theory that sPD-1 can out-compete membrane-bound PD-1 with regards to binding to its ligands (PD-L1, -L2, and CD80), thus blocking the expected inhibitory effects (15, 53). The reduced serum levels of PD-1 indicate that membrane-bound PD-1 can exert its effects with less competition from sPD-1, thereby exerting more inhibition of the inflammation seen in patients with IBD and MC. In line with our results in MC and UC patients, another study found increased levels of PD-L1 and PD-L2 mRNA in biopsies from UC patients compared with controls (54).”

In the published article, there was an error. Two ethical approval IDs and the date of one of the approvals from the Regional Ethics Review Board were stated incorrectly.

A correction has been made to the Ethics Statement. This sentence previously stated:

“The studies involving human participants were reviewed and approved by the Regional Ethics Review Board of Uppsala (2008-10-15, Ethical Approval ID #008/278) for the biopsy samples. For serum samples, approval was obtained from the Regional Ethics Review Boards of Lund (2006-06-29, ID #276/2006 and 2012-01-26, ID #2012/32) and Linköping (2012-09-05, ID #2015/216-3108 and 2015-02-05, ID #2015/31-31).”

The corrected sentence appears below:

“The studies involving human participants were reviewed and approved by the Regional Ethics Review Board of Uppsala (2008-10-15, Ethical Approval ID #2008/278) for the biopsy samples. For serum samples, approval was obtained from the Regional Ethics Review Boards of Lund (2006-06-29, ID #276/2006 and 2012-01-26, ID #2012/32) and Linköping (2012-09-05, ID #2012/216-31 and 2015-02-25, ID #2015/31-31).”

The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

References

54. Rajabian Z, Kalani F, Taghiloo S, Tehrani M, Rafiei A, Hosseini-khah Z, et al. Over-expression of immunosuppressive molecules, PD-L1 and PD-L2, in ulcerative colitis patients. Iran J Immunol. (2019) 16:62–70. doi: 10.22034/IJI.2019.39407

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