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CORRECTION article

Front. Med., 12 November 2024
Sec. Gastroenterology
Volume 11 - 2024 | https://doi.org/10.3389/fmed.2024.1506094

Corrigendum: Patients with microscopic colitis have altered levels of inhibitory and stimulatory biomarkers in colon biopsies and sera compared to non-inflamed controls

This article is a correction to:

  1. Patients With Microscopic Colitis Have Altered Levels of Inhibitory and Stimulatory Biomarkers in Colon Biopsies and Sera Compared to Non-inflamed Controls

    1. Read original article
\r\nAlexandra Lushnikova Alexandra Lushnikova1*Johan BohrJohan Bohr2Anna WickbomAnna Wickbom2Andreas MünchAndreas Münch3Klas SjbergKlas Sjöberg4Olof HultgrenOlof Hultgren5Anders WirnAnders Wirén1Elisabeth Hultgren HrnquistElisabeth Hultgren Hörnquist1
  • 1School of Medical Sciences, Örebro University, Örebro, Sweden
  • 2Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
  • 3Department of Gastroenterology and Hepatology in Linköping, and Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden
  • 4Department of Clinical Sciences, Lund University, Department of Gastroenterology, Skåne University Hospital, Malmö, Sweden
  • 5Department of Clinical Immunology and Transfusion Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

A Corrigendum on
Patients with microscopic colitis have altered levels of inhibitory and stimulatory biomarkers in colon biopsies and sera compared to non-inflamed controls

by Lushnikova, A., Bohr, J., Wickbom, A., Münch, A., Sjöberg, K., Hultgren, O., Wirén, A., and Hultgren Hörnquist, E. (2021). Front. Med. 8:727412. doi: 10.3389/fmed.2021.727412

In the published article, reference Rajabian et al. (2019) (54) was not cited in the article. The citation has now been inserted in the Discussion, paragraph 9, and should read:

“PD-1 is an inhibitory receptor expressed on activated T cells that has been reported to be upregulated in IBD (19, 52). In accordance with this, we also found increased expression in the colon of MC and UC patients with active disease. The opposite was seen in serum where levels of PD-1 were decreased. Reviews of the functions of soluble PD-1 (sPD-1) describe the theory that sPD-1 can out-compete membrane-bound PD-1 with regards to binding to its ligands (PD-L1, -L2, and CD80), thus blocking the expected inhibitory effects (15, 53). The reduced serum levels of PD-1 indicate that membrane-bound PD-1 can exert its effects with less competition from sPD-1, thereby exerting more inhibition of the inflammation seen in patients with IBD and MC. In line with our results in MC and UC patients, another study found increased levels of PD-L1 and PD-L2 mRNA in biopsies from UC patients compared with controls (54).”

In the published article, there was an error. Two ethical approval IDs and the date of one of the approvals from the Regional Ethics Review Board were stated incorrectly.

A correction has been made to the Ethics Statement. This sentence previously stated:

“The studies involving human participants were reviewed and approved by the Regional Ethics Review Board of Uppsala (2008-10-15, Ethical Approval ID #008/278) for the biopsy samples. For serum samples, approval was obtained from the Regional Ethics Review Boards of Lund (2006-06-29, ID #276/2006 and 2012-01-26, ID #2012/32) and Linköping (2012-09-05, ID #2015/216-3108 and 2015-02-05, ID #2015/31-31).”

The corrected sentence appears below:

“The studies involving human participants were reviewed and approved by the Regional Ethics Review Board of Uppsala (2008-10-15, Ethical Approval ID #2008/278) for the biopsy samples. For serum samples, approval was obtained from the Regional Ethics Review Boards of Lund (2006-06-29, ID #276/2006 and 2012-01-26, ID #2012/32) and Linköping (2012-09-05, ID #2012/216-31 and 2015-02-25, ID #2015/31-31).”

The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

References

54. Rajabian Z, Kalani F, Taghiloo S, Tehrani M, Rafiei A, Hosseini-khah Z, et al. Over-expression of immunosuppressive molecules, PD-L1 and PD-L2, in ulcerative colitis patients. Iran J Immunol. (2019) 16:62–70. doi: 10.22034/IJI.2019.39407

PubMed Abstract | Crossref Full Text | Google Scholar

Keywords: microscopic colitis, colorectal cancer, immune surveillance, immune checkpoints, ulcerative colitis, serum, colonic biopsies

Citation: Lushnikova A, Bohr J, Wickbom A, Münch A, Sjöberg K, Hultgren O, Wirén A and Hultgren Hörnquist E (2024) Corrigendum: Patients with microscopic colitis have altered levels of inhibitory and stimulatory biomarkers in colon biopsies and sera compared to non-inflamed controls. Front. Med. 11:1506094. doi: 10.3389/fmed.2024.1506094

Received: 04 October 2024; Accepted: 29 October 2024;
Published: 12 November 2024.

Edited and reviewed by: Luca Pastorelli, University of Milan, Italy

Copyright © 2024 Lushnikova, Bohr, Wickbom, Münch, Sjöberg, Hultgren, Wirén and Hultgren Hörnquist. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Alexandra Lushnikova, YWxleGFuZHJhLmx1c2huaWtvdmFAZ21haWwuY29t

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.