Skip to main content

CASE REPORT article

Front. Med.
Sec. Ophthalmology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1503795

A rare case of delayed onset granulomatous panuveitis induced by intravitreal conbercept injection

Provisionally accepted
Qiu Yu Zhuang Qiu Yu Zhuang 1*Mei Qing Ren Mei Qing Ren 2Jie Luan Jie Luan 1
  • 1 Southeast University, Nanjing, China
  • 2 Zhongda Hospital, Southeast University, Nanjing, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Uveitis is a form of eye inflammation caused by autoimmune disease, infection, injury or other factors. We report a rare case of granulomatous panuveitis following intravitreal injection of conbercept. To the best of our knowledge, none of the previous literature has described such an delayed onset complication after intravitreal injection surgery.We report a case of a 63-year-old man who suffered from neovascular age-related macular degeneration (nAMD) in both eyes and polypoidal choroidal vasculopathy (PCV) in the right eye, and then he underwent intravitreal injection surgery. 20 days after surgery, slit-lamp examination showed mutton-fat keratic precipitates (KPs) and vitritis in both eyes. Grayish-white koeppe nodule could be seen at the pupillary margin of the right eye. Vision loss, ocular pain or any systemic symptom were absent. Intraocular pressure of each eye was within normal range. Fundus fluorescein angiography (FFA) revealed fluorescein filling in the cavity of pigment epithelial detachment lesion. The results of routine blood, C-reactive protein were normal, and test for syphilis or tuberculosis infection showed negative results. Therefore, he was clinically diagnosed with bilateral drug-induced granulomatous panuveitis with the possibility of conbercept being the culprit agent. The KPs were quickly cleared after oral prednisone treatment combined with early topical application of dexamethasone eye drops, and complete resolution of bilateral uveitis was achieved by the fourth month, with best corrected visual acuity (BCVA) increased to 20/25 in the right eye and 20/20 in the left eye. Conclusion Identification of drug as the offending agent of uveitis is quite important as prompt discontinuation of the responsible drug or concomitant use of corticosteroids may help recover the uveitis. Clinicians should be aware of the possibility of late onset uveitis of intravitreal conbercept and conduct careful monitoring and appropriate treatment.

    Keywords: Drug-induced uveitis, conbercept, Intravitreal injection, NAMD, PCV

    Received: 29 Sep 2024; Accepted: 03 Dec 2024.

    Copyright: © 2024 Zhuang, Ren and Luan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qiu Yu Zhuang, Southeast University, Nanjing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.