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ORIGINAL RESEARCH article

Front. Med.
Sec. Pulmonary Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1502916

Long-term trends in the burden of Pulmonary Arterial hypertension in China and worldwide: New insights based on GBD 2021 Authors

Provisionally accepted
Zhehao XU Zhehao XU Jia Ding Jia Ding Ruiyun Liang Ruiyun Liang Shuangfeng Xie Shuangfeng Xie *
  • Sun Yat-sen Memorial Hospital, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    The goal of this study was to provide the latest and the most comprehensive burden estimates of the Pulmonary arterial hypertension (PAH) from 1990 to 2021 in China and worldwide. Data were retrieved from GBD database 2021. A comparative analysis of the differences in PAH burden between China and the world was conducted from multiple dimensions, including age, gender, and time periods. The Bayesian age-period-cohort (BAPC) model was used to project the global epidemiological trends until 2036. From 1990 and 2021, the incidence and prevalence of PAH escalated by 80.59% and 86.74% in China, respectively. The age-standardized incidence rate (ASIR) and age-standardized prevalence rate (ASPR) change with an AAPC of -0.07% and 0.25%, respectively. Conversely, the age-standardized DALY rate and age-standardized mortality rate (ASMR) exhibited a downward trend since 1990, with an AAPC of -1.90% and -1.26%, respectively. Notably, Females and 50-70 years age experienced a higher PAH burden than males throughout the period. We projected that ASPR, ASMR, and ASDR would stabilize with little variation over the next decade. In China, the burden of PAH is age-related, with a higher prevalence observed in the older population and women. Necessitating concerted efforts and attention.

    Keywords: Age-Period-Cohort analysis, pulmonary arterial hypertension, Mortality, Prevalence, projection, Global burden of disease

    Received: 27 Sep 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 XU, Ding, Liang and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Shuangfeng Xie, Sun Yat-sen Memorial Hospital, Guangzhou, 510000, Guangdong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.