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REVIEW article

Front. Med.
Sec. Gene and Cell Therapy
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1499605

AAV-based Vectors for Human Diseases Modeling in Laboratory Animals

Provisionally accepted
Timur I. Aliev Timur I. Aliev 1Dmitry V. Yudkin Dmitry V. Yudkin 2*
  • 1 Novosibirsk State University, Novosibirsk, Novosibirsk Oblast, Russia
  • 2 I.M. Sechenov First Moscow State Medical University, Moscow, Russia

The final, formatted version of the article will be published soon.

    The development of therapeutic drugs and vaccines requires the availability of appropriate model animals that replicate the pathogenesis of human diseases. Both native and transgenic animals can be utilized as models. The advantage of transgenic animals lies in their ability to simulate specific properties desired by researchers. However, there is often a need for the rapid production of transgenic animal models, especially in situations like a pandemic, as was evident during COVID-19. An important tool for transgenesis is the adeno-associated virus. The genome of adeno-associated virus serves as a convenient expression cassette for delivering various DNA constructs into cells, and this method has proven effective in practice. This review analyzes the features of the adeno-associated virus genome that make it an advantageous vector for transgenesis. Additionally, examples of utilizing adeno-associated viral vectors to create animal models for hereditary, oncological, and viral human diseases are provided.

    Keywords: adeno-associated virus, transgenesis, Animal Models, human diseases, Gene Therapy

    Received: 26 Sep 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Aliev and Yudkin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dmitry V. Yudkin, I.M. Sechenov First Moscow State Medical University, Moscow, Russia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.