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ORIGINAL RESEARCH article

Front. Med.
Sec. Pulmonary Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1497597

Disease burden and trends of lung cancer attributable to nickel among Chinese and global population: A cross-sectional study

Provisionally accepted
Huaye Lu Huaye Lu 1Han Lei Han Lei 1Peihong Wu Peihong Wu 1Xin Liu Xin Liu 1*Qingtao Jiang Qingtao Jiang 2*
  • 1 Jiangsu Provincial Center for Disease Control And Prevention, Nanjing, China
  • 2 Department of clinical medicine, Jiangsu Health Vocational College, Nanjing, China, Nanjing, Liaoning Province, China

The final, formatted version of the article will be published soon.

    Background: Nickel is a well-established carcinogen, and China stands as a significant producer of nickel compounds. Nickel-associated lung cancer is increasingly acknowledged as a pressing public health concern. This study presents a comprehensive analysis at temporal, spatial, and population levels utilizing the most recent data from GBD 2019 to estimate the disease burden of nickel-associated lung cancer from 1990 to 2019, and make predictions to 2035.We delineated data on nickel-associated lung cancer concerning mortality, disabilityadjusted life years (DALY), and age-standardized rates (ASRs) over a 30-year period based on the Global Burden of Disease (GBD) 2019. Joinpoint regression analysis was utilized to identify temporal changes and to estimate the annual percentage change (APC) as well as the average annual percentage change (AAPC) for each trend segment. The Nordpred model was employed to elaborate on ASRs trends from 1990 to 2019, along with projections for the subsequent 15 years.In both China and globally, the mortality rate from nickel-associated lung cancer and the associated DALYs have increased by 145.8%, 77.8%, 120.2%, and 64.6%, respectively. ASRs within Chinese and global populations exhibit a pattern characterized by an initial increase followed by a decrease as age progresses, with males higher than females. The trend for DALY indicates an initial rise followed by a decline, peaking in the year 2027.The age structure of nickel-associated lung cancer patients shows an aging trend, and the ASDR in the Chinese population indicates a potential upward trend when projecting the disease burden

    Keywords: Global Burden of Disease (GBD), Disability-adjusted life years (DALY), Nickel, lung cancer, prediction

    Received: 17 Sep 2024; Accepted: 04 Dec 2024.

    Copyright: © 2024 Lu, Lei, Wu, Liu and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xin Liu, Jiangsu Provincial Center for Disease Control And Prevention, Nanjing, China
    Qingtao Jiang, Department of clinical medicine, Jiangsu Health Vocational College, Nanjing, China, Nanjing, Liaoning Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.