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ORIGINAL RESEARCH article

Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1497245
This article is part of the Research Topic Heart Failure and Arrhythmia View all 3 articles

Association between the heart rate to temperature ratio and 28-day mortality in patients with heart failure in the intensive care unit: a multicenter retrospective cohort study patients with heart failure : a multicenter retrospective cohort study

Provisionally accepted
Cheng Fu Cheng Fu 1*Weiguo Lin Weiguo Lin 2Xinglin Chen Xinglin Chen 3WeiLi Hong WeiLi Hong 2*Shaorong Yan Shaorong Yan 2*Yuzhan L Yuzhan L 2*
  • 1 Ruian Traditional Chinese Medicine Hospital, Ruian 325200, Zhejiang Province, China, China
  • 2 Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
  • 3 Department of Epidemiology and Biostatistics, Empower U, X&Y solutions Inc., Boston, United States

The final, formatted version of the article will be published soon.

    Abstract Background: Heart failure (HF) is a life-threatening condition with a high mortality rate. The precise relationship between the heart rate and temperature (HR/T) ratio and mortality in patients with HF remains unclear. This study aimed to investigate the relationship between the HR/T ratio and 28-day intensive care unit (ICU) mortality rates in patients with HF. Methods: This retrospective cohort study analyzed the data of 3,790 patients with congestive heart failure in a large electronic database. Patients were divided into quartiles based on their HR/T ratio: Q1 (1.28–1.76), Q2 (2.44–2.72), Q3 (2.88–3.14), and Q4 (3.29–4.13). Multivariable logistic regression analysis was performed to examine the association between HR/T ratio and 28-day ICU mortality. Results: Patients with higher HR/T ratios had greater disease severity and higher mortality rates. In the fully adjusted regression model, a significant association was observed between HR/T ratio and 28-day ICU mortality risk, with mortality increasing as HR/T ratio rose (OR = 1.55, 95% CI: 1.17–2.04). An E-value analysis indicated that unmeasured confounders had a minimal impact on the results, confirming the robustness of the study. Conclusion: Among ICU-admitted patients with HF, we identified a significant association between HR/T ratio and 28-day ICU mortality. As the HR/T ratio increased, the 28-day ICU mortality showed an upward trend.

    Keywords: Heart Failure, Heart Rate, temperature, Mortality, Intensive Care Unit

    Received: 16 Sep 2024; Accepted: 03 Dec 2024.

    Copyright: © 2024 Fu, Lin, Chen, Hong, Yan and L. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Cheng Fu, Ruian Traditional Chinese Medicine Hospital, Ruian 325200, Zhejiang Province, China, China
    WeiLi Hong, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
    Shaorong Yan, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
    Yuzhan L, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.