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ORIGINAL RESEARCH article

Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1496966

Plasma neutrophil extracellular traps in patients with sepsisinduced acute kidney injury serves as a new biomarker to predict 28-day survival outcomes of disease

Provisionally accepted
Jian He Jian He Feng Zheng Feng Zheng Lihua Qiu Lihua Qiu Yilan Wang Yilan Wang Jing Zhang Jing Zhang Hongwei Ye Hongwei Ye Qian Zhang Qian Zhang *
  • Changshu No.1 People's Hospital, Suzhou, China

The final, formatted version of the article will be published soon.

    Background: There is no accurate and readily available, validated biomarker for assessing disease severity and survival outcome in sepsis-induced acute kidney injury (SAKI), which is a limitation to conduct therapeutic interventions. The neutrophil extracellular traps (NETs) may be involving in the pathophysiology of SAKI. The present study investigated the predictive value of plasma NETs for survival outcome of patients with SAKI. Method: This observational study included 136 SAKI patients, who obtained a 28-day follow-up. According to the records of follow-up, SAKI patients were divided into two groups: non-survive group (60 subjects) and survive group (76 subjects). Blood samples were collected after the diagnosis of AKI for measurement of three NETs markers and 12 inflammatory indices. Correlation analysis, logistic regression analysis, receiver operating characteristic curve analysis, and survival analysis were performed. Results: Compared with survivors in SAKI patients, three plasma NETs markers showed significantly increased levels in non-survivors (all p < 0.001). Meanwhile, in SAKI patients, plasma levels of NETs markers were significantly associated with serum levels of inflammatory indices, and serum interleukin (IL) -2, IL-8, IL-10, and tumour necrosis factor alpha showed an interactive effect with plasma NETs markers on the survival of SAKI patients. Furthermore, the combination of three plasma NETs markers could identify SAKI patients with a poor 28-day survival with a better accuracy (area under the curve = 0.857). Finally, plasma NETs markers could independently predict the 28-day survival in SAKI patients. Conclusion: Plasma NETs markers were increased levels in SAKI patients with a poor outcome, and served as biomarkers to predict 28-day survival in SAKI patients.

    Keywords: Acute Kidney Injury, Inflammation, neutrophil extracellular traps, Sepsis, Survival

    Received: 16 Sep 2024; Accepted: 04 Nov 2024.

    Copyright: © 2024 He, Zheng, Qiu, Wang, Zhang, Ye and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qian Zhang, Changshu No.1 People's Hospital, Suzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.