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ORIGINAL RESEARCH article

Front. Med.
Sec. Pulmonary Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1493463

Red cell distribution width to albumin ratio is associated with asthma risk: A population-based study

Provisionally accepted
Jinzhen Ding Jinzhen Ding 1,2Yixiang Zhang Yixiang Zhang 1,2Xiaoyang Chen Xiaoyang Chen 1,2*
  • 1 Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian, Quanzhou, Fujian, 362200, China., Quanzhou, China
  • 2 Medical University, Respirology Medicine Centre of Fujian Province, Quanzhou, China., Quanzhou, China

The final, formatted version of the article will be published soon.

    The red cell distribution width to albumin ratio (RAR), a newly identified biomarker of inflammation, has been linked to a variety of inflammatory diseases.Asthma, a major burden on global health, is an inflammatory airway disease that is profoundly affected by inflammation. This study primarily sought to examine the influence of RAR on the risk of developing asthma.Methods: Data from 1999-2020 was gathered from the NHANES database. The impact of RAR on asthma risk and their nonlinear relationship were clarified by multivariate logit and restricted cubic spline (RCS) analyses. Subgroup and interaction analyses collectively formed the sensitivity analysis for this study.Results: This study was based on an analysis of 54,161 individuals. RAR has been identified as an independent risk factor for asthma, according to logit analysis. The moderate and high RAR groups had a 16% (95% confidence interval (CI): 1.06-1.27) and 43% (95% CI: 1.30-1.58) higher risk respectively, compared to the lowest group. Every 0.5 unit increase in RAR almost doubled the risk of asthma (odds ratio (OR):1.82, 95% CI: 1.55-2.12). There was no non-linear relationship between RAR and asthma risk, based on RCS analysis. Combining subgroup and interaction analyses results, all subgroups in this study showed consistent trends with the overall population.Notably, this article, the first to examine the relationship between RAR and asthma risk, unveiled a positive linear correlation between them. With an increase in RAR, whether analyzed as a categorical or continuous variable, asthma risk significantly increases. This finding was beneficial for clinicians to anticipate and assess the onset of asthma through stratified or dynamic management. Given RARs numerous advantages, its application in clinical settings held considerable promise.

    Keywords: Red cell distribution width to albumin ratio, Asthma, NHANES, risk, Inflammation

    Received: 09 Sep 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 Ding, Zhang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiaoyang Chen, Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian, Quanzhou, Fujian, 362200, China., Quanzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.