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ORIGINAL RESEARCH article

Front. Med.
Sec. Geriatric Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1492603

Association Between Diabetes Mellitus and Trochanteric Bone Mineral Density in Individuals with Osteoporotic Fractures: A Retrospective Study

Provisionally accepted
Shao-Han Guo Shao-Han Guo 1Jian Xu Jian Xu 2Min-Zhe Xu Min-Zhe Xu 1Chong Li Chong Li 1Ya-Qin Gong Ya-Qin Gong 3Ke Lu Ke Lu 1*
  • 1 Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, Liaoning Province, China
  • 2 Department of Orthopedics, The First People’s Hospital of Kunshan, Gusu School, Nanjing Medical University, Suzhou, Liaoning Province, China
  • 3 Information Department, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, Liaoning Province, China

The final, formatted version of the article will be published soon.

    The relationship between diabetes mellitus (DM) and bone mineral density (BMD) in patients with osteoporotic fractures (OPFs) remains complex and heterogeneous, specifically between the genders. This study aimed to explore the association between diabetes status and trochanteric BMD in a cohort of patients with OPFs and elucidate the differences between male and female patients.Methods: This retrospective analysis was performed on 710 admitted patients aged 50 years or older with OPFs. In this study, the exposure variable was diabetes status. Trochanteric BMD comprised the dependent variable. While controlling for covariance influences, generalized estimating equations (GEE) were applied to examine the independent link between diabetes status and trochanteric BMD in OPFs patients. Moreover, a subgroup analysis was also conducted to validate the result's stability.Results: A substantial positive association was noted between diabetes status and trochanteric BMD in diabetic patients, as determined by the fully adjusted model (β = 0.017, 95% CI 0.001 to 0.033, p = 0.035).Furthermore, the sex-specific analysis showed a significant positive relationship between diabetes status and trochanteric BMD in male patients (β = 0.040, 95% CI 0.006 to 0.075, p = 0.022), whereas no significant relationship was observed in female patients (β = 0.010, 95% CI -0.008 to 0.028, p = 0.256).This study highlighted the significant sex differences in the impact of diabetes on trochanteric BMD among patients with OPFs. The male diabetic patients had higher trochanteric BMD than their non-diabetic counterparts; however, this association was not evident in female patients. Further research is necessary to understand the underlying mechanisms that contribute to these sex-specific differences and to evaluate the clinical implications of managing fracture risk in diabetic patients.

    Keywords: Osteoporotic Fractures, diabetes, bone mineral density, Sex-specific effects, Retrospective

    Received: 07 Sep 2024; Accepted: 28 Nov 2024.

    Copyright: © 2024 Guo, Xu, Xu, Li, Gong and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ke Lu, Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, Liaoning Province, China

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