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REVIEW article

Front. Med.
Sec. Hepatobiliary Diseases
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1490929

The role of intestinal flora in metabolic dysfunction-associated steatotic liver disease and treatment strategies

Provisionally accepted
Lijun Wang Lijun Wang 1*Jianguang Sun Jianguang Sun 2Shu Cheng CHEN Shu Cheng CHEN 3Yuli Sun Yuli Sun 2Yang Zheng Yang Zheng 4Jianchao Feng Jianchao Feng 4
  • 1 Binzhou Medical University, Binzhou, China
  • 2 Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
  • 3 Hong Kong Polytechnic University, Kowloon, Hong Kong, SAR China
  • 4 Zibo Central Hospital, Shandong, China

The final, formatted version of the article will be published soon.

    Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common multi-factorial liver disease, and its incidence is gradually increasing worldwide. Many reports have revealed that intestinal flora plays a crucial role for the occurrence and development of MASLD, through mechanisms such as flora translocation, endogenous ethanol production, dysregulation of choline metabolism and bile acid, and endotoxemia. Here, we review the relationship between intestinal flora and MASLD, as well as interventions for MASLD, such as prebiotics, probiotics, synbiotics, and intestinal flora transplantation. Intervention strategies targeting the intestinal flora along with its metabolites may be new targets for preventing and treating MASLD.

    Keywords: intestinal flora, Metabolic dysfunction-associated steatotic liver disease, Probiotics, Metabolism, review

    Received: 04 Sep 2024; Accepted: 28 Nov 2024.

    Copyright: © 2024 Wang, Sun, CHEN, Sun, Zheng and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lijun Wang, Binzhou Medical University, Binzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.