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SYSTEMATIC REVIEW article

Front. Med.
Sec. Gastroenterology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1490506
This article is part of the Research Topic Microbiome impact on inflammatory bowel diseases View all articles

Prevalence and predictors of small intestinal bacterial overgrowth in inflammatory bowel disease: A meta-analysis

Provisionally accepted
Xin Feng Xin Feng Jie Hu Jie Hu Xin Zhang Xin Zhang *
  • The People’s Hospital of Yubei District of Chongqing City, Chongqing, China

The final, formatted version of the article will be published soon.

    Small intestinal bacterial overgrowth (SIBO) has been reported to be very common among individuals with inflammatory bowel disease (IBD), and the prevalence of SIBO is highly variable. We conducted this study to calculate the prevalence and identify predictors of SIBO in IBD.PubMed, Cochrane Library, and EMBASE from inception to March 2024 were searched for studies evaluating the prevalence of SIBO in IBD. We calculated the pooled prevalence of SIBO among IBD patients and the odds ratio (OR) of SIBO in IBD compared with healthy controls. Besides, we also evaluated predictors of SIBO in IBD patients.Twenty-nine studies (3250 IBD, 708 controls) were included in our study. The pooled prevalence of SIBO in IBD was 31.0% (95% CI 25.2-37.1), and the prevalence of SIBO was higher in IBD compared with healthy controls (OR 5.25, 95% CI 2.96-9.32). The pooled prevalence of SIBO was higher among CD patients (32.2%, 95% CI 25.9-38.8) compared with UC patients (27.8%, 95% CI 18.5-38.1). The odds of lower BMI (mean difference = -1.04; 95% CI -1.86--0.23), bloating (OR=3.02, 95% CI 1.22-7.5), flatulence (OR=4.70, 95% CI 1.44-15.35), history of abdominal surgery (OR=2.05, 95% CI 1.35-3.11), and stricturing/penetrating disease behavior (OR=3.51, 95% CI 1.67-7.40) increased significantly in IBD patients with SIBO compared to those without SIBO. Antibiotic treatment may be effective for SIBO in IBD patients.Nearly one-third of IBD patients present with SIBO positive, and the odds of SIBO in IBD was increased by 5.25-fold compared with healthy controls. Lower BMI, bloating, flatulence, history of abdominal surgery, and stricturing/penetrating disease behavior were predictors of SIBO in IBD patients.

    Keywords: small intestinal bacterial overgrowth, inflammatory bowel disease, Meta-analysis, ulcerative colitis, Crohn's disease (CD)

    Received: 03 Sep 2024; Accepted: 11 Dec 2024.

    Copyright: © 2024 Feng, Hu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xin Zhang, The People’s Hospital of Yubei District of Chongqing City, Chongqing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.