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ORIGINAL RESEARCH article

Front. Med.
Sec. Pathology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1488727
This article is part of the Research Topic Regulation of intervertebral disc homeostasis and the pathological or pathophysiological alterations under various harmful stimuli during aging process View all articles

Allogeneic fibroblasts ameliorate intervertebral disc degeneration by reducing osteophytes in rabbits

Provisionally accepted
Chen Chen Chen Chen 1Yizhuo Huang Yizhuo Huang 1Lei Shi Lei Shi 1Li Zhou Li Zhou 2Hongjin Wan Hongjin Wan 1Xiao Yang Xiao Yang 1Shen'Ao Zhou Shen'Ao Zhou 3Jie Zhao Jie Zhao 1*
  • 1 Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai, China
  • 2 FibroX Therapeutics Inc., Shanghai, China, shanghai, China
  • 3 Celliver Biotechnology Inc., Shanghai, China., shanghai, China

The final, formatted version of the article will be published soon.

    Low back pain (LBP) was commonly induced by intervertebral disc degeneration (IVDD), which is accompanied by the loss of disc height and osteophyte generation. Cell-based therapy is a promising treatment for preventing the degeneration of interverbal disc. Here, we established a rabbits-derived fibroblast (Rab-Fib) which could be expanded in vitro. On puncture induced intervertebral disc degeneration (IVDD) rat models, Rab-Fib had significant therapeutic effects as X-ray, CT and MRI results indicated an exceptional mitigation of disc degeneration. Therefore, this study could be a foundation of further applying fibroblast into clinical trials.

    Keywords: IVDD, Interverbal disc, interverbal disc degeneration, ALLO = allogeneic, fibroblast

    Received: 30 Aug 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Chen, Huang, Shi, Zhou, Wan, Yang, Zhou and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jie Zhao, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.