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REVIEW article

Front. Med.
Sec. Geriatric Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1488536

A bibliometric analysis of exosomes in aging from 2007 to 2023

Provisionally accepted
Zenghui Niu Zenghui Niu 1Meiyu Cui Meiyu Cui 1Yingkun Fu Yingkun Fu 1*Lingfeng Zhou Lingfeng Zhou 1*Jiali Wang Jiali Wang 1,2*Yan Lei Yan Lei 1*Xinrong Fan Xinrong Fan 1*Qiang Wang Qiang Wang 3*Jing Yang Jing Yang 1*
  • 1 China Academy of Chinese Medical Sciences, Beijing, China
  • 2 Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China
  • 3 Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Background: Aging is the primary factor contributing to the development of agingrelated diseases. As research on exosomes continues to advance, its relationship with aging and aging-related diseases has become a hot topic This article analyzes the research hotspots of exosomes in aging and aging-related diseases, aiming to fill the gap in bibliometric research in this field and help researchers better understand the current status and future trends of both fundamental and clinical research in this field.Methods: The articles were retrieved and exported from WoSCC on December 18, 2023. The visual analysis of countries and regions, institutions, authors, references, and keywords in exosomes of aging was conducted using VOSviewer 1.6.18, CiteSpace 6.2.R7, and Bibliometrix. Results: The bibliometric analysis included 1628 articles. China and the United States emerged as the top two leading countries in this field. A total of 2,321 research institutions from 78 countries and regions were primarily led by China and the United States. Both Kapogiannis D and Goetzl E were active authors in this field. Thery C, Valadi H, and Raposo G were the important promoters in this field. Thery C proposed the method of differential centrifugation and density gradient centrifugation to extract exosomes. Valadi H discovered cells could send RNA-messages to each other by loading them into exosome-vesicles. The journal with the highest number of articles was International Journal of Molecular Sciences, while PLoS One was the most frequently cited journal. The keyword analysis revealed that future research on exosomes in aging will possibly focus on "inflammation, cellular senescence, angiogenesis, insulin resistance, and Alzheimer's disease". Conclusion: We identified the research trends of exosomes in the field of aging through this bibliometric analysis. The present study provides valuable new perspectives on the history and current status of exosomes in the field of aging and aging-related diseases, and also offering guidance for future research directions.

    Keywords: Bibliometric, Exosomes, Aging, senescence, aging-related diseases

    Received: 30 Aug 2024; Accepted: 04 Nov 2024.

    Copyright: © 2024 Niu, Cui, Fu, Zhou, Wang, Lei, Fan, Wang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yingkun Fu, China Academy of Chinese Medical Sciences, Beijing, China
    Lingfeng Zhou, China Academy of Chinese Medical Sciences, Beijing, China
    Jiali Wang, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, 300120, China
    Yan Lei, China Academy of Chinese Medical Sciences, Beijing, China
    Xinrong Fan, China Academy of Chinese Medical Sciences, Beijing, China
    Qiang Wang, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
    Jing Yang, China Academy of Chinese Medical Sciences, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.