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ORIGINAL RESEARCH article

Front. Med.
Sec. Geriatric Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1486807
This article is part of the Research Topic Advances in the Pathogenesis and Treatment of Osteoporosis: From Bench to Bedside View all 6 articles

Biological aging mediates the associations between obstructive sleep apnea syndrome and osteoarthritis based on the NHANES

Provisionally accepted
Xin Luo Xin Luo 1Minghong Chen Minghong Chen 1Jinghong Xu Jinghong Xu 2*
  • 1 Xiangya Hospital, Central South University, Changsha, Hunan Province, China
  • 2 University of Science and Technology of China, Hefei, China

The final, formatted version of the article will be published soon.

    Background: Osteoarthritis (OA) is characterized by high morbidity and disability. Given studies have illuminated OA is correlated with age-related diseases, few research showed the potential relationship between OA and obstructive sleep apnea syndrome (OSAS). OSAS is featured by intermittent hypoxia and hypercapnia, we hypothesized these stressors induced ageing and increased OA prevalence.The study included 10641 participants from NHANES dataset in 2005-2008 and 2015-2018 years. The correlation between OSAS and OA was analyzed by multivariable logistic regression, calculated aging-related biomarkers and explored aging role by mediation analysis. Results: OSAS elevated the risk of OA (for quartile 4 vs. quartile 1, OR 2.31, 95%CI 1.34 to 3.99; P for trend = 0.004) after adjusting covariates; in 20-59 and > 60 years subgroup with OSAS patients had similarly trend (for quartile 4 vs. quartile 1, OR 5.69, 95%CI 2.75 to 11.8; P for trend < 0.001; OR 2.42, 95%CI 1.23 to 4.76; P for trend = 0.004, respectively). Further mediation analysis revealed that aging acted as a mediator between OA and OSAS (Biological age and phenotypic age mediation proportion were 13.82% and 52.94%, P < 0.001).These findings suggested people who had OSAS may boost the prevalence of OA and aging was also involved.

    Keywords: aging1, NHANES2, osteoarthritis3, obstructive sleep apnea syndrome4 aging, NHANES, osteoarthritis, obstructive sleep apnea syndrome ACME, average causal mediation effects, ADE, average direct effects), biological age, BA, Chronic obstructive pulmonary disease, COPD, confidence interval, CI, National Health and Nutrition Examination Survey, NHANES, obstructive sleep apnea syndrome, OSAS, osteoarthritis, OA

    Received: 26 Aug 2024; Accepted: 05 Nov 2024.

    Copyright: © 2024 Luo, Chen and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jinghong Xu, University of Science and Technology of China, Hefei, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.