The final, formatted version of the article will be published soon.
REVIEW article
Front. Med.
Sec. Pulmonary Medicine
Volume 11 - 2024 |
doi: 10.3389/fmed.2024.1486780
This article is part of the Research Topic Eosinophilic Inflammation in Chronic Lung Diseases: Emerging Molecular Insights and Therapeutic Strategy View all 3 articles
IL-18 biology in Severe Asthma
Provisionally accepted
Sarita Thawanaphong
1,2
Aswathi Nair
1,2
Emily Volfson
1,2
Parameswaran K. Nair
1,2
Manali Mukherjee
1,2*- 1 McMaster University, Hamilton, Canada
- 2 St. Joseph's Healthcare, Hamilton, Ontario, Canada
The role of interleukin-18 (IL-18) and inflammasomes in chronic inflammatory airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), has garnered significant attention in recent years. This review aims to provide an overview of the current understanding of IL-18 biology, the associated signalling pathways, and the involvement of inflammasome complexes in airway diseases. We explore the multifaceted role of IL-18 in asthma pathophysiology, including its interactions with other cytokines and contributions to both T2 and non-T2 inflammation. Importantly, emerging evidence highlights IL-18 as a critical player in severe asthma, contributing to chronic airway inflammation, airway hyperresponsiveness (AHR), and mucus impaction. Furthermore, we discuss the emerging evidence of IL-18's involvement in autoimmunity and highlight potential therapeutic targets within the IL-18 and inflammasome pathways in severe asthma patients with evidence of infections and airway autoimmune responses. By synthesizing recent advancements and ongoing research, this review underscores the importance of IL-18 as a potential novel therapeutic target in the treatment of severe asthma and other related conditions.
Keywords: IL-18, Autoimmunity, Asthma, Inflammasome, Eosinophilia
Received: 26 Aug 2024; Accepted: 18 Oct 2024.
Copyright: © 2024 Thawanaphong, Nair, Volfson, Nair and Mukherjee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Manali Mukherjee, McMaster University, Hamilton, Canada
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.