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ORIGINAL RESEARCH article
Front. Med.
Sec. Nephrology
Volume 11 - 2024 |
doi: 10.3389/fmed.2024.1486702
A comparative study to evaluate the nailfold microcirculation in non-dialysis chronic kidney disease patients
Provisionally accepted- 1 The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
- 2 Clinical Research Center For Kidney Disease Xuzhou Medical University, Xuzhou, China
- 3 Second Affiliated Hospital, Xuzhou Medical University, Xuzhou, Jiangsu Province, China
Chronic kidney disease (CKD) is commonly associated with vascular injury. To rapidly evaluate microcirculation in non-dialysis CKD patients, we utilized nailfold capillaroscopy to study their nailfold microcirculation. A total of 104 participants were recruited for the study, including 63 non-dialysis CKD patients (CKD group) and 41 healthy individuals (control group). Renal function-related tests and nailfold microcirculation examinations were performed for all participants. We compared 20 nailfold microcirculation indexes between the two groups and further analyzed correlations between these indexes and serum creatinine (Scr), blood urea nitrogen (BUN), cystatin C, estimated glomerular filtration rate (eGFR), CKD stage, and hemoglobin (Hb) in the CKD group. Our findings revealed that Scr, BUN, cystatin C and CKD stage were positively correlated with the capillary number integral, while eGFR and Hb was negatively correlated. Additionally, Scr, cystatin C, and CKD stage were negatively correlated with the subpapillary venular plexus integral, whereas eGFR was positively correlated. In conclusion, our study indicates that the nailfold microcirculation in non-dialysis CKD patients is significantly altered compared to healthy individuals. These changes are primarily characterized by a reduction in nailfold capillary number and diastolic dysfunction of the subpapillary venular plexus.
Keywords: Nailfold microcirculation, Chronic Kidney Disease, Non-dialysis, capillary number, subpapillary venular plexus Trial Registration Clinical Trials.gov (NCT03682952)
Received: 26 Aug 2024; Accepted: 09 Dec 2024.
Copyright: © 2024 Li, Yan, Zhou, Liu, Raj, Wang and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shulin Li, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Han Yan, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Zhuzhu Liu, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Disheng Wang, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Dong Sun, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
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